Contractile properties of the developing fetal sheep bladder

Peter Nyirády, Nikesh Thiruchelvam, Margaret L. Godley, Anna David, Peter M. Cuckow, Christopher H. Fry

Research output: Contribution to journalArticle

7 Citations (Scopus)


Aim: To characterise the developmental changes to the normal bladder by examining the in vitro contractile properties of the fetal sheep detrusor smooth muscle bladder at different gestational ages. Methods: Three groups of normally developing fetal sheep bladders were investigated: (1) 65-70 days gestation (2nd trimester); (2) 105-110days (3rd trimester); (3) 135-140 days (term). Isometric contractions in isolated detrusor strips were measured during either electrical field stimulation (EPS) or exposure to agonists: carbachol, α-β methylene-ATP (ABMA) and KCl. Results: There was a significant increase of absolute force elicited by EFS with fetal age. Contractures elicited by carbachol, ABMA and KCl increased between Groups 1 and 2, but not thereafter. The proportional increase of contractions elicited by carbachol and ABMA was also greater between Groups 1 and 2, than for EFS and KCl. Conclusions: Fetal development between 65 and 140 days in the sheep is associated with increased contractile activation. The data are consistent with an increase of muscle development in the earlier stages (65-110 days). In the later stage (110-140 days) muscle development is complete but functional innervation of the tissue continues.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalNeurourology and Urodynamics
Issue number3
Publication statusPublished - May 17 2005


  • Detrusor muscle
  • Development
  • Muscarinic receptors
  • Nerves

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

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    Nyirády, P., Thiruchelvam, N., Godley, M. L., David, A., Cuckow, P. M., & Fry, C. H. (2005). Contractile properties of the developing fetal sheep bladder. Neurourology and Urodynamics, 24(3), 276-281.