Contraceptive Treatment Increases the Affinity of Uterine Estrogen Receptor in Adult Rat

Perinatal Gestagen Treatment Changes the Reaction

G. Csaba, A'gnes Inczefi Gonda, Cs Karabélyos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Uterus estrogen receptor affinity increases in adult rats if treated with contraceptive, without receptor density change. Uterus estrogen receptor density decreases in adulthood following allylestrenol (Gestanon) treatment perinatally with receptor affinity unchanging. In perinatally allylestrenol treated rats contraceptive treatment resulted in the decrease of receptor affinity and increase of density, related to the only perinatally allylestrenol treated animals. The results draw attention to the fact that contraceptives may influence the estrogen receptor state of the uterus and the pregnancy maintaining treatment (by allylestrenol) may influence the state of uterine estrogen receptors for life via the later effect of contraceptives commonly dosed.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalHormone and Metabolic Research
Volume28
Issue number1
Publication statusPublished - 1996

Fingerprint

Allylestrenol
Progestins
Contraceptive Agents
Estrogen Receptors
Rats
Uterus
Animals
Pregnancy

Keywords

  • Allylestrenol
  • Contraceptives
  • Estrogen Receptor
  • Gestagen
  • Hormonal Imprinting

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Contraceptive Treatment Increases the Affinity of Uterine Estrogen Receptor in Adult Rat : Perinatal Gestagen Treatment Changes the Reaction. / Csaba, G.; Inczefi Gonda, A'gnes; Karabélyos, Cs.

In: Hormone and Metabolic Research, Vol. 28, No. 1, 1996, p. 16-19.

Research output: Contribution to journalArticle

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