Contraceptive efficacy, compliance and beyond: Factors related to satisfaction with once-weekly transdermal compared with oral contraception

Wolfgang Urdl, Dan Apter, Alan Alperstein, Peter Koll, Siegfried Schönian, Jacques Bringer, Alan C. Fisher, Michael Preik, G. Freude, H. Kittl, A. Staudach, W. Urdl, J. Amy, M. Degueldre, M. Dhont, A. Van Assche, U. Ågren, D. Apter, E. Granfors, T. JärviH. Polvi, P. Sipilä, S. Telimaa, E. Varila, G. Body, J. Bringer, G. Chaix-Durand, B. Hedon, J. L. Meyer, C. Quereux, F. Sailly, E. Signon, M. Tournaire, K. Greven, R. Klopfer, U. Kohoutek, L. Koos, S. Schönian, R. Schöpp, K. Stahmer, H. G. Weidenhammer, A. Borsos, L. Kovacs, Z. Papp, I. Rákóczi, S. Friese, F. Helmerhorst, M. V. Kroeks, A. Pennings, L. Pijpers, F. Roumen, J. Schram, H. K. Van Weering, A. Malarewicz, S. Radowicki, S. Rozewicki, P. Skalba, M. Szamatowicz, A. Warenik, A. Alperstein, J. Baker, H. Cronjé, V. A. Hulme, T. Katzeff, P. Koll, J. Moodley, H. C. Odendaal, L. Reynders, G. Tsalacopoulos, Z. M. Van Der Spuy, A. Campana, M. Germond

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective: To investigate contraceptive efficacy, compliance and user's satisfaction with transdermal versus oral contraception (OC). Study design: Randomized, open-label, parallel-group trial conducted at 65 centers in Europe and South Africa. One thousand four hundred and eighty-nine women received a contraceptive patch (n = 846) or an OC (n = 643) for 6 or 13 cycles. Results: Overall/method-failure Pearl Indices were 0.88/0.66 with the patch and 0.56/0.28 with the OC (p = n.s.). Compliance was higher at all age groups with the patch compared to the OC. Significantly more users were very satisfied with the contraceptive patch than with the OC. The percentage of patch users being very satisfied increased with age whereas it did not in the OC group. Likewise, improvements of premenstrual symptoms as well as emotional and physical well-being increased with age in the patch-group in contrast to the OC group. Ratings of satisfaction with the study medication correlated weakly with emotional (r = 0.33) and physical well-being (r = 0.39) as well as premenstrual symptoms (r = 0.30; p <0.001). Conclusion: Contraceptive efficacy of the patch is comparable to OC, but compliance is consistently better at all age groups. Higher satisfaction with the patch at increasing age may be attributed to improvements in emotional and physical well-being as well as reduction of premenstrual symptoms.

Original languageEnglish
Pages (from-to)202-210
Number of pages9
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume121
Issue number2
DOIs
Publication statusPublished - Aug 1 2005

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Contraceptive Agents
Contraception
Compliance
Age Groups
South Africa

Keywords

  • Compliance
  • Efficacy
  • Oral contraceptive
  • Safety
  • Satisfaction
  • Transdermal contraceptive patch

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Contraceptive efficacy, compliance and beyond : Factors related to satisfaction with once-weekly transdermal compared with oral contraception. / Urdl, Wolfgang; Apter, Dan; Alperstein, Alan; Koll, Peter; Schönian, Siegfried; Bringer, Jacques; Fisher, Alan C.; Preik, Michael; Freude, G.; Kittl, H.; Staudach, A.; Urdl, W.; Amy, J.; Degueldre, M.; Dhont, M.; Van Assche, A.; Ågren, U.; Apter, D.; Granfors, E.; Järvi, T.; Polvi, H.; Sipilä, P.; Telimaa, S.; Varila, E.; Body, G.; Bringer, J.; Chaix-Durand, G.; Hedon, B.; Meyer, J. L.; Quereux, C.; Sailly, F.; Signon, E.; Tournaire, M.; Greven, K.; Klopfer, R.; Kohoutek, U.; Koos, L.; Schönian, S.; Schöpp, R.; Stahmer, K.; Weidenhammer, H. G.; Borsos, A.; Kovacs, L.; Papp, Z.; Rákóczi, I.; Friese, S.; Helmerhorst, F.; Kroeks, M. V.; Pennings, A.; Pijpers, L.; Roumen, F.; Schram, J.; Van Weering, H. K.; Malarewicz, A.; Radowicki, S.; Rozewicki, S.; Skalba, P.; Szamatowicz, M.; Warenik, A.; Alperstein, A.; Baker, J.; Cronjé, H.; Hulme, V. A.; Katzeff, T.; Koll, P.; Moodley, J.; Odendaal, H. C.; Reynders, L.; Tsalacopoulos, G.; Van Der Spuy, Z. M.; Campana, A.; Germond, M.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 121, No. 2, 01.08.2005, p. 202-210.

Research output: Contribution to journalArticle

Urdl, W, Apter, D, Alperstein, A, Koll, P, Schönian, S, Bringer, J, Fisher, AC, Preik, M, Freude, G, Kittl, H, Staudach, A, Urdl, W, Amy, J, Degueldre, M, Dhont, M, Van Assche, A, Ågren, U, Apter, D, Granfors, E, Järvi, T, Polvi, H, Sipilä, P, Telimaa, S, Varila, E, Body, G, Bringer, J, Chaix-Durand, G, Hedon, B, Meyer, JL, Quereux, C, Sailly, F, Signon, E, Tournaire, M, Greven, K, Klopfer, R, Kohoutek, U, Koos, L, Schönian, S, Schöpp, R, Stahmer, K, Weidenhammer, HG, Borsos, A, Kovacs, L, Papp, Z, Rákóczi, I, Friese, S, Helmerhorst, F, Kroeks, MV, Pennings, A, Pijpers, L, Roumen, F, Schram, J, Van Weering, HK, Malarewicz, A, Radowicki, S, Rozewicki, S, Skalba, P, Szamatowicz, M, Warenik, A, Alperstein, A, Baker, J, Cronjé, H, Hulme, VA, Katzeff, T, Koll, P, Moodley, J, Odendaal, HC, Reynders, L, Tsalacopoulos, G, Van Der Spuy, ZM, Campana, A & Germond, M 2005, 'Contraceptive efficacy, compliance and beyond: Factors related to satisfaction with once-weekly transdermal compared with oral contraception', European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 121, no. 2, pp. 202-210. https://doi.org/10.1016/j.ejogrb.2005.01.021
Urdl, Wolfgang ; Apter, Dan ; Alperstein, Alan ; Koll, Peter ; Schönian, Siegfried ; Bringer, Jacques ; Fisher, Alan C. ; Preik, Michael ; Freude, G. ; Kittl, H. ; Staudach, A. ; Urdl, W. ; Amy, J. ; Degueldre, M. ; Dhont, M. ; Van Assche, A. ; Ågren, U. ; Apter, D. ; Granfors, E. ; Järvi, T. ; Polvi, H. ; Sipilä, P. ; Telimaa, S. ; Varila, E. ; Body, G. ; Bringer, J. ; Chaix-Durand, G. ; Hedon, B. ; Meyer, J. L. ; Quereux, C. ; Sailly, F. ; Signon, E. ; Tournaire, M. ; Greven, K. ; Klopfer, R. ; Kohoutek, U. ; Koos, L. ; Schönian, S. ; Schöpp, R. ; Stahmer, K. ; Weidenhammer, H. G. ; Borsos, A. ; Kovacs, L. ; Papp, Z. ; Rákóczi, I. ; Friese, S. ; Helmerhorst, F. ; Kroeks, M. V. ; Pennings, A. ; Pijpers, L. ; Roumen, F. ; Schram, J. ; Van Weering, H. K. ; Malarewicz, A. ; Radowicki, S. ; Rozewicki, S. ; Skalba, P. ; Szamatowicz, M. ; Warenik, A. ; Alperstein, A. ; Baker, J. ; Cronjé, H. ; Hulme, V. A. ; Katzeff, T. ; Koll, P. ; Moodley, J. ; Odendaal, H. C. ; Reynders, L. ; Tsalacopoulos, G. ; Van Der Spuy, Z. M. ; Campana, A. ; Germond, M. / Contraceptive efficacy, compliance and beyond : Factors related to satisfaction with once-weekly transdermal compared with oral contraception. In: European Journal of Obstetrics Gynecology and Reproductive Biology. 2005 ; Vol. 121, No. 2. pp. 202-210.
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abstract = "Objective: To investigate contraceptive efficacy, compliance and user's satisfaction with transdermal versus oral contraception (OC). Study design: Randomized, open-label, parallel-group trial conducted at 65 centers in Europe and South Africa. One thousand four hundred and eighty-nine women received a contraceptive patch (n = 846) or an OC (n = 643) for 6 or 13 cycles. Results: Overall/method-failure Pearl Indices were 0.88/0.66 with the patch and 0.56/0.28 with the OC (p = n.s.). Compliance was higher at all age groups with the patch compared to the OC. Significantly more users were very satisfied with the contraceptive patch than with the OC. The percentage of patch users being very satisfied increased with age whereas it did not in the OC group. Likewise, improvements of premenstrual symptoms as well as emotional and physical well-being increased with age in the patch-group in contrast to the OC group. Ratings of satisfaction with the study medication correlated weakly with emotional (r = 0.33) and physical well-being (r = 0.39) as well as premenstrual symptoms (r = 0.30; p <0.001). Conclusion: Contraceptive efficacy of the patch is comparable to OC, but compliance is consistently better at all age groups. Higher satisfaction with the patch at increasing age may be attributed to improvements in emotional and physical well-being as well as reduction of premenstrual symptoms.",
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T1 - Contraceptive efficacy, compliance and beyond

T2 - Factors related to satisfaction with once-weekly transdermal compared with oral contraception

AU - Urdl, Wolfgang

AU - Apter, Dan

AU - Alperstein, Alan

AU - Koll, Peter

AU - Schönian, Siegfried

AU - Bringer, Jacques

AU - Fisher, Alan C.

AU - Preik, Michael

AU - Freude, G.

AU - Kittl, H.

AU - Staudach, A.

AU - Urdl, W.

AU - Amy, J.

AU - Degueldre, M.

AU - Dhont, M.

AU - Van Assche, A.

AU - Ågren, U.

AU - Apter, D.

AU - Granfors, E.

AU - Järvi, T.

AU - Polvi, H.

AU - Sipilä, P.

AU - Telimaa, S.

AU - Varila, E.

AU - Body, G.

AU - Bringer, J.

AU - Chaix-Durand, G.

AU - Hedon, B.

AU - Meyer, J. L.

AU - Quereux, C.

AU - Sailly, F.

AU - Signon, E.

AU - Tournaire, M.

AU - Greven, K.

AU - Klopfer, R.

AU - Kohoutek, U.

AU - Koos, L.

AU - Schönian, S.

AU - Schöpp, R.

AU - Stahmer, K.

AU - Weidenhammer, H. G.

AU - Borsos, A.

AU - Kovacs, L.

AU - Papp, Z.

AU - Rákóczi, I.

AU - Friese, S.

AU - Helmerhorst, F.

AU - Kroeks, M. V.

AU - Pennings, A.

AU - Pijpers, L.

AU - Roumen, F.

AU - Schram, J.

AU - Van Weering, H. K.

AU - Malarewicz, A.

AU - Radowicki, S.

AU - Rozewicki, S.

AU - Skalba, P.

AU - Szamatowicz, M.

AU - Warenik, A.

AU - Alperstein, A.

AU - Baker, J.

AU - Cronjé, H.

AU - Hulme, V. A.

AU - Katzeff, T.

AU - Koll, P.

AU - Moodley, J.

AU - Odendaal, H. C.

AU - Reynders, L.

AU - Tsalacopoulos, G.

AU - Van Der Spuy, Z. M.

AU - Campana, A.

AU - Germond, M.

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Objective: To investigate contraceptive efficacy, compliance and user's satisfaction with transdermal versus oral contraception (OC). Study design: Randomized, open-label, parallel-group trial conducted at 65 centers in Europe and South Africa. One thousand four hundred and eighty-nine women received a contraceptive patch (n = 846) or an OC (n = 643) for 6 or 13 cycles. Results: Overall/method-failure Pearl Indices were 0.88/0.66 with the patch and 0.56/0.28 with the OC (p = n.s.). Compliance was higher at all age groups with the patch compared to the OC. Significantly more users were very satisfied with the contraceptive patch than with the OC. The percentage of patch users being very satisfied increased with age whereas it did not in the OC group. Likewise, improvements of premenstrual symptoms as well as emotional and physical well-being increased with age in the patch-group in contrast to the OC group. Ratings of satisfaction with the study medication correlated weakly with emotional (r = 0.33) and physical well-being (r = 0.39) as well as premenstrual symptoms (r = 0.30; p <0.001). Conclusion: Contraceptive efficacy of the patch is comparable to OC, but compliance is consistently better at all age groups. Higher satisfaction with the patch at increasing age may be attributed to improvements in emotional and physical well-being as well as reduction of premenstrual symptoms.

AB - Objective: To investigate contraceptive efficacy, compliance and user's satisfaction with transdermal versus oral contraception (OC). Study design: Randomized, open-label, parallel-group trial conducted at 65 centers in Europe and South Africa. One thousand four hundred and eighty-nine women received a contraceptive patch (n = 846) or an OC (n = 643) for 6 or 13 cycles. Results: Overall/method-failure Pearl Indices were 0.88/0.66 with the patch and 0.56/0.28 with the OC (p = n.s.). Compliance was higher at all age groups with the patch compared to the OC. Significantly more users were very satisfied with the contraceptive patch than with the OC. The percentage of patch users being very satisfied increased with age whereas it did not in the OC group. Likewise, improvements of premenstrual symptoms as well as emotional and physical well-being increased with age in the patch-group in contrast to the OC group. Ratings of satisfaction with the study medication correlated weakly with emotional (r = 0.33) and physical well-being (r = 0.39) as well as premenstrual symptoms (r = 0.30; p <0.001). Conclusion: Contraceptive efficacy of the patch is comparable to OC, but compliance is consistently better at all age groups. Higher satisfaction with the patch at increasing age may be attributed to improvements in emotional and physical well-being as well as reduction of premenstrual symptoms.

KW - Compliance

KW - Efficacy

KW - Oral contraceptive

KW - Safety

KW - Satisfaction

KW - Transdermal contraceptive patch

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