Continuous versus intermittent levofloxacin treatment in complicated urinary tract infections caused by urinary obstruction temporarily relieved by foreign body insertion

P. Tenke, Bela Kovacs, R. Benkó, David Ashaber, E. Nagy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was one of the first to examine the in vivo levofloxacin adsorption to stent surfaces. The results demonstrated the ability of this antibiotic to adsorb to the conditioning film and to the surface of the inserted device, and showed that 1-2 weeks after the discontinuation of antibiotic administration some amount of the antibiotic still could be detected on them. The second aim of the investigation was to determine whether continuous or intermittent levofloxacin treatment is advantageous for the patients who have acute complicated urinary tract infection (UTI) caused by urinary obstruction. The results did not show any clinical or microbiological advantages of the continuous therapy.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume28
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Levofloxacin
Foreign Bodies
Urinary Tract Infections
Anti-Bacterial Agents
Adsorption
Stents
Therapeutics
Equipment and Supplies

Keywords

  • Antibiotic adsorption
  • Biofilm
  • Conditioning film
  • Continuous therapy
  • Intermittent therapy
  • Stent surface

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

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AU - Nagy, E.

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