Continuous thrombolysis and repeated thrombectomy with the penumbra system™ in a child with hemorrhagic sinus thrombosis: Technical note

Zsolt Kulcsár, Miklós Marosfoi, Zsolt Berentei, István Szikora

Research output: Contribution to journalArticle

21 Citations (Scopus)


Summary Cerebral venous sinus thrombosis (CVST) is an uncommon but potentially lethal event. When showing a malignant clinical course despite anticoagulant therapy, new endovascular techniques and technology allow the possibility of more aggressive thrombolysis and thrombectomy. The authors present a case of recanalization of an extensive cerebral thrombosis using a new endovascular thromboaspiration device, the Penumbra System™. Background and purpose CVST in children is a rare but potentially lethal disorder. When showing a malignant progression despite anticoagulant therapy, the use of local thrombolytics and thrombectomy procedures might provide therapeutic solution. Methods A 16-year-old girl presented with signs and symptoms of a hemorrhagic cerebral sinus thrombosis and showed progression despite full dose anticoagulant therapy. The evolution being attributed to increasing mass effect, decompressive surgery was performed without clinical improvement. Further brain imaging demonstrated progression of the sinus thrombosis. Repeated local thrombectomy with the Penumbra thrombectomy system and continuous, relatively low dose local thrombolysis was performed during a period of 60 h, resulting in recanalization and clinical improvement. The methodology of combined thromboaspiration and thrombolysis is described. Conclusions We present a novel method for revascularization using the Penumbra System™ in combination with long-term, relatively low dose thrombolysis, in the setting of both clinically and morphologically progressive, hemorrhagic sinus thrombosis. The procedure proved to be both safe and effective and may be considered in the future for patients with progressive sinovenous thrombosis despite adequate medical therapy.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalActa neurochirurgica
Issue number5
Publication statusPublished - May 1 2010


  • Sinus thrombosis
  • Thrombectomy
  • Thromboaspiration
  • Thrombolysis
  • Urokinase

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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