Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Róbert Örkényi, János Éles, F. Faigl, Péter Vincze, Anita Prechl, Zoltán Szakács, János Kóti, István Greiner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Continuous-flow multistep synthesis is combined with quasi-continuous final-product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co- and by-products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual-mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.

Original languageEnglish
Pages (from-to)8742-8745
Number of pages4
JournalAngewandte Chemie - International Edition
Volume56
Issue number30
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • centrifugal partition chromatography
  • continuous flow chemistry
  • multistep synthesis
  • purification

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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