Continuous manufacturing of orally dissolving webs containing a poorly soluble drug via electrospinning

András Domokos, Attila Balogh, Dániel Dénes, Gyula Nyerges, Levente Ződi, Balázs Farkas, G. Marosi, Zsombor Kristóf Nagy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An orally dissolving web (ODW) formulation of poorly soluble carvedilol (CAR) was developed and manufactured continuously using electrospinning (ES) as a key technology. Phase solubility tests revealed that hydroxypropyl-β-cyclodextrin (HPβCD) solubilizer alone cannot ensure sufficient solubility (6.25 mg CAR in 20 mL) in the oral cavity even if citric acid was present to ionize the basic drug. In turn, electrospun amorphous nanofibers of polyvinylpyrrolidone K30 (PVPK30) and CAR exhibited notable supersaturation of the drug in the presence of citric acid. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) confirmed the amorphous state of CAR. The final ODW was prepared by layering the nanofibers onto pullulan, a well-soluble polysaccharide film carrying citric acid. The double-layered formulation showed ultrafast disintegration and dissolution modeling the oral cavity meeting regulatory requirements (<30 s). The continuous production was accomplished using our recently developed continuous model system by controlled deposition of the nanofibers onto the carrier film strained to a wheel collector and followed by cutting into final dosage units. Performance tests of the continuous system revealed satisfactory content uniformity over time (average acceptance value = 9.45), while residual solvent content measurements showed trace amounts of ethanol (EtOH) after production and acceptable dimethyl-formamide (DMF) content with secondary drying at room temperature. The presented work demonstrates how ES can be part of a continuous manufacturing system as an advanced drying tool during the formulation of challenging drugs.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalEuropean Journal of Pharmaceutical Sciences
Volume130
DOIs
Publication statusPublished - Mar 15 2019

Keywords

  • Continuous manufacturing
  • Dissolution enhancement
  • Electrospinning
  • Oral drug delivery
  • Orally dissolving web
  • Poorly soluble drug

ASJC Scopus subject areas

  • Pharmaceutical Science

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