Continuous flow synthesis of heterocyclic scaffolds

Design principles of multistep systems - A review

Klára Lövei, Péter Bana, Róbert Örkényi, György I. Túrós, János Éles, Z. Novák, Ferenc Faigl

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The synthesis of novel heterocycles is an essential task in small-molecule drug discovery. Continuous flow processing opens the way for a new paradigm in laboratory-scale synthesis as well as pharmaceutical manufacturing. Based on our experiences with the multistep synthesis of condensed benzothiazoles, we gathered some of the key design features in light of literature examples.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalChimica Oggi/Chemistry Today
Volume34
Issue number4
Publication statusPublished - Jul 1 2016

Fingerprint

Scaffolds
Benzothiazoles
Molecules
Processing
Pharmaceutical Preparations
Drug Discovery

Keywords

  • Condensed heterocycles
  • Continuous flow synthesis
  • Multistep flow synthesis
  • Scaffold
  • Telescoping

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Lövei, K., Bana, P., Örkényi, R., Túrós, G. I., Éles, J., Novák, Z., & Faigl, F. (2016). Continuous flow synthesis of heterocyclic scaffolds: Design principles of multistep systems - A review. Chimica Oggi/Chemistry Today, 34(4), 18-21.

Continuous flow synthesis of heterocyclic scaffolds : Design principles of multistep systems - A review. / Lövei, Klára; Bana, Péter; Örkényi, Róbert; Túrós, György I.; Éles, János; Novák, Z.; Faigl, Ferenc.

In: Chimica Oggi/Chemistry Today, Vol. 34, No. 4, 01.07.2016, p. 18-21.

Research output: Contribution to journalReview article

Lövei, K, Bana, P, Örkényi, R, Túrós, GI, Éles, J, Novák, Z & Faigl, F 2016, 'Continuous flow synthesis of heterocyclic scaffolds: Design principles of multistep systems - A review', Chimica Oggi/Chemistry Today, vol. 34, no. 4, pp. 18-21.
Lövei, Klára ; Bana, Péter ; Örkényi, Róbert ; Túrós, György I. ; Éles, János ; Novák, Z. ; Faigl, Ferenc. / Continuous flow synthesis of heterocyclic scaffolds : Design principles of multistep systems - A review. In: Chimica Oggi/Chemistry Today. 2016 ; Vol. 34, No. 4. pp. 18-21.
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