Continuous-flow synthesis of 3,5-disubstituted pyrazoles: Via sequential alkyne homocoupling and Cope-type hydroamination

Sándor B. Ötvös, Ádám Georgiádes, Dániel Ozsvár, F. Fülöp

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A flow chemistry-based approach is presented for the synthesis of 3,5-disubstituted pyrazoles via sequential copper-mediated alkyne homocoupling and Cope-type hydroamination of the intermediary 1,3-diynes in the presence of hydrazine as nucleophilic reaction partner. The proposed multistep methodology offers an easy and direct access to valuable pyrazoles from cheap and readily available starting materials and without the need for the isolation of any intermediates.

Original languageEnglish
Pages (from-to)8197-8203
Number of pages7
JournalRSC Advances
Volume9
Issue number15
DOIs
Publication statusPublished - Jan 1 2019

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Pyrazoles
Alkynes
hydrazine
Hydrazine
Diynes
Copper

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Continuous-flow synthesis of 3,5-disubstituted pyrazoles : Via sequential alkyne homocoupling and Cope-type hydroamination. / Ötvös, Sándor B.; Georgiádes, Ádám; Ozsvár, Dániel; Fülöp, F.

In: RSC Advances, Vol. 9, No. 15, 01.01.2019, p. 8197-8203.

Research output: Contribution to journalArticle

Ötvös, Sándor B. ; Georgiádes, Ádám ; Ozsvár, Dániel ; Fülöp, F. / Continuous-flow synthesis of 3,5-disubstituted pyrazoles : Via sequential alkyne homocoupling and Cope-type hydroamination. In: RSC Advances. 2019 ; Vol. 9, No. 15. pp. 8197-8203.
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