Continuous flow synthesis of α-aryl-α-aminophosphonates

Erika Bálint, Ádám Tajti, Katalin Ladányi-Pára, Nóra Tóth, Béla Mátravölgyi, G. Keglevich

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The synthesis of α-aryl-α-aminophosphonates was performed by the three-component Kabachnik-Fields reaction of primary amines, benzaldehyde derivatives and dialkyl phosphites in a continuous flow microwave reactor. The target compounds could be obtained in high (~90%) yields without any catalyst in simple alcohols as the solvent. The flow process elaborated required shorter reaction times and lower excess of the reagent, as compared to the "traditional" batch reactions, and allowed the synthesis of the α-aminophosphonates on a somewhat larger scale.

Original languageEnglish
JournalPure and Applied Chemistry
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Phosphites
Amines
Alcohols
Microwaves
Derivatives
Catalysts
benzaldehyde

Keywords

  • continuous flow reactor
  • ICPC-22
  • Kabachnik-Fields reaction
  • microwave
  • Pudovik reaction
  • α-aminophosphonates

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Bálint, E., Tajti, Á., Ladányi-Pára, K., Tóth, N., Mátravölgyi, B., & Keglevich, G. (Accepted/In press). Continuous flow synthesis of α-aryl-α-aminophosphonates. Pure and Applied Chemistry. https://doi.org/10.1515/pac-2018-0923

Continuous flow synthesis of α-aryl-α-aminophosphonates. / Bálint, Erika; Tajti, Ádám; Ladányi-Pára, Katalin; Tóth, Nóra; Mátravölgyi, Béla; Keglevich, G.

In: Pure and Applied Chemistry, 01.01.2018.

Research output: Contribution to journalArticle

Bálint, Erika ; Tajti, Ádám ; Ladányi-Pára, Katalin ; Tóth, Nóra ; Mátravölgyi, Béla ; Keglevich, G. / Continuous flow synthesis of α-aryl-α-aminophosphonates. In: Pure and Applied Chemistry. 2018.
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