Continuous-flow retro-Diels-Alder reaction: An efficient method for the preparation of pyrimidinone derivatives

Imane Nekkaa, Márta Palkó, István M. Mándity, Ferenc Fülöp

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume14
DOIs
Publication statusPublished - Feb 1 2018

Keywords

  • Continuous-flow
  • Desulfurisation
  • Norbornene-fused heterocycles
  • Pyrimidinones
  • Retro-Diels-Alder reaction

ASJC Scopus subject areas

  • Organic Chemistry

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