Continuous enteral feeding has an attenuating effect on the exocrine pancreas in rats

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Abstract

Introduction: Recent clinical observations suggest that continuous enteral feeding (CEF) may exert a beneficial effect in the management of inflammatory pancreatic diseases. Its effects on the exocrine pancreas, however, remain only partially investigated. Aim: To examine the effects of CEF on the exocrine pancreas in rats. Methodology: Eight male Wistar rats were intrajejunally cannulated, and CEF was started on postoperative day 6. In 10 control animals, laparotomy was followed by intragastric feeding (GF) with the same nutriment (Osmolite, Abbott) from postoperative day 6. The daily discharge was 24 kcal in both groups. After 5 days of feeding, the pancreas was removed; its weight and its protein, DNA, trypsin, and lipase contents were determined; and the exocrine pancreas was also examined for structural changes. Results: The results revealed no significant difference in body weight loss between the two groups of animals, whereas the pancreas weight/body weight ratio was lower (p <0.01) in the CEF group. The pancreatic protein, DNA, and enzyme contents were decreased (p <0.01) after CEF as compared with the values for the GF group. Histologic examinations demonstrated clear decreases in acinar size and in the zymogen content of the pancreas in the CEF animals. Conclusion: This study clearly indicates that CEF reduces the enzyme production of the pancreas.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalPancreas.
Volume23
Issue number3
DOIs
Publication statusPublished - 2001

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Exocrine Pancreas
Enteral Nutrition
Pancreas
Body Weight
Weights and Measures
Pancreatic Diseases
Enzyme Precursors
DNA
Enzymes
Lipase
Laparotomy
Trypsin
Wistar Rats
Weight Loss
Proteins

Keywords

  • Continuous enteral feeding
  • Enzymes
  • Pancreas
  • Rat

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology

Cite this

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title = "Continuous enteral feeding has an attenuating effect on the exocrine pancreas in rats",
abstract = "Introduction: Recent clinical observations suggest that continuous enteral feeding (CEF) may exert a beneficial effect in the management of inflammatory pancreatic diseases. Its effects on the exocrine pancreas, however, remain only partially investigated. Aim: To examine the effects of CEF on the exocrine pancreas in rats. Methodology: Eight male Wistar rats were intrajejunally cannulated, and CEF was started on postoperative day 6. In 10 control animals, laparotomy was followed by intragastric feeding (GF) with the same nutriment (Osmolite, Abbott) from postoperative day 6. The daily discharge was 24 kcal in both groups. After 5 days of feeding, the pancreas was removed; its weight and its protein, DNA, trypsin, and lipase contents were determined; and the exocrine pancreas was also examined for structural changes. Results: The results revealed no significant difference in body weight loss between the two groups of animals, whereas the pancreas weight/body weight ratio was lower (p <0.01) in the CEF group. The pancreatic protein, DNA, and enzyme contents were decreased (p <0.01) after CEF as compared with the values for the GF group. Histologic examinations demonstrated clear decreases in acinar size and in the zymogen content of the pancreas in the CEF animals. Conclusion: This study clearly indicates that CEF reduces the enzyme production of the pancreas.",
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author = "T. Wittmann and R. R{\'o}ka and P. Pal{\'a}gyi and L. Czak{\'o} and K. J{\'a}rmay and A. Roszt{\'o}czy and J. Lonovics",
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T1 - Continuous enteral feeding has an attenuating effect on the exocrine pancreas in rats

AU - Wittmann, T.

AU - Róka, R.

AU - Palágyi, P.

AU - Czakó, L.

AU - Jármay, K.

AU - Rosztóczy, A.

AU - Lonovics, J.

PY - 2001

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N2 - Introduction: Recent clinical observations suggest that continuous enteral feeding (CEF) may exert a beneficial effect in the management of inflammatory pancreatic diseases. Its effects on the exocrine pancreas, however, remain only partially investigated. Aim: To examine the effects of CEF on the exocrine pancreas in rats. Methodology: Eight male Wistar rats were intrajejunally cannulated, and CEF was started on postoperative day 6. In 10 control animals, laparotomy was followed by intragastric feeding (GF) with the same nutriment (Osmolite, Abbott) from postoperative day 6. The daily discharge was 24 kcal in both groups. After 5 days of feeding, the pancreas was removed; its weight and its protein, DNA, trypsin, and lipase contents were determined; and the exocrine pancreas was also examined for structural changes. Results: The results revealed no significant difference in body weight loss between the two groups of animals, whereas the pancreas weight/body weight ratio was lower (p <0.01) in the CEF group. The pancreatic protein, DNA, and enzyme contents were decreased (p <0.01) after CEF as compared with the values for the GF group. Histologic examinations demonstrated clear decreases in acinar size and in the zymogen content of the pancreas in the CEF animals. Conclusion: This study clearly indicates that CEF reduces the enzyme production of the pancreas.

AB - Introduction: Recent clinical observations suggest that continuous enteral feeding (CEF) may exert a beneficial effect in the management of inflammatory pancreatic diseases. Its effects on the exocrine pancreas, however, remain only partially investigated. Aim: To examine the effects of CEF on the exocrine pancreas in rats. Methodology: Eight male Wistar rats were intrajejunally cannulated, and CEF was started on postoperative day 6. In 10 control animals, laparotomy was followed by intragastric feeding (GF) with the same nutriment (Osmolite, Abbott) from postoperative day 6. The daily discharge was 24 kcal in both groups. After 5 days of feeding, the pancreas was removed; its weight and its protein, DNA, trypsin, and lipase contents were determined; and the exocrine pancreas was also examined for structural changes. Results: The results revealed no significant difference in body weight loss between the two groups of animals, whereas the pancreas weight/body weight ratio was lower (p <0.01) in the CEF group. The pancreatic protein, DNA, and enzyme contents were decreased (p <0.01) after CEF as compared with the values for the GF group. Histologic examinations demonstrated clear decreases in acinar size and in the zymogen content of the pancreas in the CEF animals. Conclusion: This study clearly indicates that CEF reduces the enzyme production of the pancreas.

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