Continuous enantioselective hydrogenation of activated ketones on a pt-cd chiral catalyst: Use of h-cube reactor system

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Abstract

The Pt-alumina-CD catalyzed enantioselective hydrogenations of ethylpyruvate (EP), ketopantolactone (KPL) and methyl benzoylformate (MBF) have been studied at first in an H-Cube flow hydrogenator in toluene and toluene + acetic acid. Based on the experience of previous studies carried out in batch-reactor and continuous flow systems, some parameters were kept constant (amount of catalyst, 380 mg; substrate concentration, 0.18 mol/L; temperature, 283 K), whereas others, namely chiral modifier (CD) concentration, hydrogen pressure and total liquid flow (TLF: substrate + modifier + solvent) were varied. In the course of enantioselective hydrogenation (R)-products were formed in excess: in the case of EP, KPL, MBF: 90, 60, 80 % enantioselectivities were obtained.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalReaction Kinetics and Catalysis Letters
Volume88
Issue number2
DOIs
Publication statusPublished - Aug 1 2006

Keywords

  • Asymmetric
  • Enantioselective
  • Ethyl pyruvate
  • Fixed-bed reactor
  • Hydrogenation
  • Ketopantolactone
  • Methyl benzoylformate
  • Platinum-cinchonidine catalyst

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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