Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting

Panna Vass, Zsombor K. Nagy, Rita Kóczián, Csaba Fehér, Balázs Démuth, Edina Szabó, Sune K. Andersen, Tamás Vigh, Geert Verreck, István Csontos, György Marosi, Edit Hirsch

Research output: Contribution to journalArticle

Abstract

The goals of this work were to evaluate if high-speed electrospinning can be used as a gentle and continuous drying technology to produce protein-containing cyclodextrin-based fibers from an aqueous solution and to convert the produced protein-cyclodextrin fibers into a directly compressible powder. A 400 mL/h feeding rate was used during the electrospinning experiments, corresponding to a ~270 g/h production rate of the dried material. The produced fibers were collected in a cyclone. The fibers were found grindable without secondary drying, and the ground powder was mixed with tableting excipients and was successfully tableted by direct compression. The model protein-type drug (β-galactosidase) remained stable during each of the processing steps (electrospinning, grinding, tableting) and after 6 months of storage at room temperature in the tablets. The obtained results demonstrate that high speed electrospinning can be a gentle alternative to traditional drying methods used for protein-type drugs, and that tablet formulation is achievable from the electrospun material prepared this way.

Original languageEnglish
Article number105089
JournalEuropean Journal of Pharmaceutical Sciences
Volume141
DOIs
Publication statusPublished - Jan 1 2020

Fingerprint

Powders
Cyclodextrins
Pharmaceutical Preparations
Tablets
Proteins
Cyclonic Storms
Drug Compounding
Excipients
beta-Galactosidase
Technology
Temperature
2-hydroxypropyl-beta-cyclodextrin

Keywords

  • Aqueous electrospinning
  • Cyclodextrin, biopharmaceuticals
  • Oral dosage form
  • Protein
  • Scale-up
  • Tableting

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting. / Vass, Panna; Nagy, Zsombor K.; Kóczián, Rita; Fehér, Csaba; Démuth, Balázs; Szabó, Edina; Andersen, Sune K.; Vigh, Tamás; Verreck, Geert; Csontos, István; Marosi, György; Hirsch, Edit.

In: European Journal of Pharmaceutical Sciences, Vol. 141, 105089, 01.01.2020.

Research output: Contribution to journalArticle

Vass, Panna ; Nagy, Zsombor K. ; Kóczián, Rita ; Fehér, Csaba ; Démuth, Balázs ; Szabó, Edina ; Andersen, Sune K. ; Vigh, Tamás ; Verreck, Geert ; Csontos, István ; Marosi, György ; Hirsch, Edit. / Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting. In: European Journal of Pharmaceutical Sciences. 2020 ; Vol. 141.
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