Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease

P. Amair, R. Khanna, B. Leibel, A. Pierratos, S. Vas, E. Meema, G. Blair, L. Chisolm, M. Vas, W. Zingg, G. Digenis, D. Oreopoulos

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Abstract

Twenty diabetics with end-stage renal disease who had never previously received dialysis treatment were treated with continuous ambulatory peritoneal dialysis for periods of two to 36 months (average, 14.5). Intraperitoneal administration of insulin creatinine clearance decreased significantly (P = 0.001), control of blood urea nitrogen and serum creatinine was adequate. Hemoglobin and serum albumin levels increased significantly (P = 0.005 and 0.04, respectively). Similarly, there was a significant increase in serum triglycerides and alkaline phosphatase (P = 0.02 and 0.05). Blood pressure became normal without medications in all but one of the patients. Retinopathy, neuropathy, and osteodystrophy remained unchanged. Peritonitis developed once in every 20.6 patient-months - a rate similar to that observed in nondiabetics. The calculated survival rate was 93 per cent at one year; the calculated rate of continuation on ambulatory peritoneal dialysis was 87 per cent. We conclude that continuous ambulatory dialysis with intraperitoneal administration of insulin is a good alternative treatment for diabetics with end-stage renal disease.

Original languageEnglish
Pages (from-to)625-630
Number of pages6
JournalNew England Journal of Medicine
Volume306
Issue number11
Publication statusPublished - 1982

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Continuous Ambulatory Peritoneal Dialysis
Chronic Kidney Failure
Dialysis
Creatinine
Insulin
Blood Urea Nitrogen
Peritoneal Dialysis
Peritonitis
Serum
Serum Albumin
Alkaline Phosphatase
Hemoglobins
Triglycerides
Survival Rate
Blood Pressure
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Amair, P., Khanna, R., Leibel, B., Pierratos, A., Vas, S., Meema, E., ... Oreopoulos, D. (1982). Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease. New England Journal of Medicine, 306(11), 625-630.

Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease. / Amair, P.; Khanna, R.; Leibel, B.; Pierratos, A.; Vas, S.; Meema, E.; Blair, G.; Chisolm, L.; Vas, M.; Zingg, W.; Digenis, G.; Oreopoulos, D.

In: New England Journal of Medicine, Vol. 306, No. 11, 1982, p. 625-630.

Research output: Contribution to journalArticle

Amair, P, Khanna, R, Leibel, B, Pierratos, A, Vas, S, Meema, E, Blair, G, Chisolm, L, Vas, M, Zingg, W, Digenis, G & Oreopoulos, D 1982, 'Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease', New England Journal of Medicine, vol. 306, no. 11, pp. 625-630.
Amair P, Khanna R, Leibel B, Pierratos A, Vas S, Meema E et al. Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease. New England Journal of Medicine. 1982;306(11):625-630.
Amair, P. ; Khanna, R. ; Leibel, B. ; Pierratos, A. ; Vas, S. ; Meema, E. ; Blair, G. ; Chisolm, L. ; Vas, M. ; Zingg, W. ; Digenis, G. ; Oreopoulos, D. / Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease. In: New England Journal of Medicine. 1982 ; Vol. 306, No. 11. pp. 625-630.
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AU - Amair, P.

AU - Khanna, R.

AU - Leibel, B.

AU - Pierratos, A.

AU - Vas, S.

AU - Meema, E.

AU - Blair, G.

AU - Chisolm, L.

AU - Vas, M.

AU - Zingg, W.

AU - Digenis, G.

AU - Oreopoulos, D.

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AB - Twenty diabetics with end-stage renal disease who had never previously received dialysis treatment were treated with continuous ambulatory peritoneal dialysis for periods of two to 36 months (average, 14.5). Intraperitoneal administration of insulin creatinine clearance decreased significantly (P = 0.001), control of blood urea nitrogen and serum creatinine was adequate. Hemoglobin and serum albumin levels increased significantly (P = 0.005 and 0.04, respectively). Similarly, there was a significant increase in serum triglycerides and alkaline phosphatase (P = 0.02 and 0.05). Blood pressure became normal without medications in all but one of the patients. Retinopathy, neuropathy, and osteodystrophy remained unchanged. Peritonitis developed once in every 20.6 patient-months - a rate similar to that observed in nondiabetics. The calculated survival rate was 93 per cent at one year; the calculated rate of continuation on ambulatory peritoneal dialysis was 87 per cent. We conclude that continuous ambulatory dialysis with intraperitoneal administration of insulin is a good alternative treatment for diabetics with end-stage renal disease.

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