Contemporary personalized β-blocker management in the perioperative setting

Adriana D. Oprea, Xiaoxiao Wang, Robert Sickeler, Miklos D. Kertai

Research output: Contribution to journalReview article

Abstract

Beta-adrenergic blockers (β-blockers) are clearly indicated for the long-term treatment of patients with systolic heart failure and post-acute myocardial infarction. Early small-scale studies reported their potential benefits for perioperative use; subsequent randomized controlled trials, however, failed to reproduce earlier findings. Furthermore, their role in reducing major postoperative cardiac events following noncardiac and cardiac surgery remains controversial. This case-based review presents an overview of contemporary literature on perioperative β-blocker use with a focus on data available since 2008 when the PreOperative ISchemic Evaluation (POISE) trial was published. Our review suggests that studies should determine the effects of situational-based guidelines on perioperative β-blocker use on the risk of cardiac adverse events and mortality in the perioperative period.

Original languageEnglish
JournalJournal of Anesthesia
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Systolic Heart Failure
Literature
Perioperative Period
Adrenergic beta-Antagonists
Thoracic Surgery
Randomized Controlled Trials
Myocardial Infarction
Guidelines
Mortality
Therapeutics

Keywords

  • Cardiac surgery
  • Noncardiac surgery
  • Outcomes
  • β-Blockers

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Contemporary personalized β-blocker management in the perioperative setting. / Oprea, Adriana D.; Wang, Xiaoxiao; Sickeler, Robert; Kertai, Miklos D.

In: Journal of Anesthesia, 01.01.2019.

Research output: Contribution to journalReview article

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