Contact solvents for common bile duct stones: Study in an in vitro system

M. Guitaoui, A. M. Montet, T. Takács, J. C. Montet

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalLiver
Volume15
Issue number5
Publication statusPublished - 1995

Fingerprint

Common Bile Duct
Dithioerythritol
Cholesterol
Expectorants
Deoxycholic Acid
Acetylcysteine
Dimethyl Sulfoxide
Bilirubin
Fatty Acids
In Vitro Techniques

Keywords

  • Bile duct
  • Bilirubin
  • Cholesterol
  • Dissolution
  • Solvents
  • Stones

ASJC Scopus subject areas

  • Hepatology

Cite this

Guitaoui, M., Montet, A. M., Takács, T., & Montet, J. C. (1995). Contact solvents for common bile duct stones: Study in an in vitro system. Liver, 15(5), 247-252.

Contact solvents for common bile duct stones : Study in an in vitro system. / Guitaoui, M.; Montet, A. M.; Takács, T.; Montet, J. C.

In: Liver, Vol. 15, No. 5, 1995, p. 247-252.

Research output: Contribution to journalArticle

Guitaoui, M, Montet, AM, Takács, T & Montet, JC 1995, 'Contact solvents for common bile duct stones: Study in an in vitro system', Liver, vol. 15, no. 5, pp. 247-252.
Guitaoui, M. ; Montet, A. M. ; Takács, T. ; Montet, J. C. / Contact solvents for common bile duct stones : Study in an in vitro system. In: Liver. 1995 ; Vol. 15, No. 5. pp. 247-252.
@article{71d4b48431264854852c8d9e52012c91,
title = "Contact solvents for common bile duct stones: Study in an in vitro system",
abstract = "Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p",
keywords = "Bile duct, Bilirubin, Cholesterol, Dissolution, Solvents, Stones",
author = "M. Guitaoui and Montet, {A. M.} and T. Tak{\'a}cs and Montet, {J. C.}",
year = "1995",
language = "English",
volume = "15",
pages = "247--252",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Contact solvents for common bile duct stones

T2 - Study in an in vitro system

AU - Guitaoui, M.

AU - Montet, A. M.

AU - Takács, T.

AU - Montet, J. C.

PY - 1995

Y1 - 1995

N2 - Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p

AB - Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p

KW - Bile duct

KW - Bilirubin

KW - Cholesterol

KW - Dissolution

KW - Solvents

KW - Stones

UR - http://www.scopus.com/inward/record.url?scp=0029122304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029122304&partnerID=8YFLogxK

M3 - Article

C2 - 8531594

AN - SCOPUS:0029122304

VL - 15

SP - 247

EP - 252

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 5

ER -