Abstract
Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p
| Original language | English |
|---|---|
| Pages (from-to) | 247-252 |
| Number of pages | 6 |
| Journal | Liver |
| Volume | 15 |
| Issue number | 5 |
| Publication status | Published - 1995 |
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Keywords
- Bile duct
- Bilirubin
- Cholesterol
- Dissolution
- Solvents
- Stones
ASJC Scopus subject areas
- Hepatology
Cite this
Contact solvents for common bile duct stones : Study in an in vitro system. / Guitaoui, M.; Montet, A. M.; Takács, T.; Montet, J. C.
In: Liver, Vol. 15, No. 5, 1995, p. 247-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contact solvents for common bile duct stones
T2 - Study in an in vitro system
AU - Guitaoui, M.
AU - Montet, A. M.
AU - Takács, T.
AU - Montet, J. C.
PY - 1995
Y1 - 1995
N2 - Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p
AB - Cholesterol and brown pigment stones found in the common bile duct are often radiolucent and therefore indistinguishable. The purpose of this study was to define contact solvent systems able to dissolve both stone types. The influence of mucolytic agents on in vitro pigment stone dissolution was first determined. It was shown that dithioerythritol induced more rapid dissolution than N-acetylcysteine. Alternating treatment with an aqueous alkaline solvent (pH = 9.5), composed of sodium deoxycholate 50 mM, ethylenediaminetetraacetate 26 mM and dithioerythritol 50 mM, for 45 min, and an organic solvent methyl tert-butyl ether/dimethyl sulfoxide (90/10) for 15 min, was more effective for bilirubin, cholesterol, and fatty acid solubilization (p
KW - Bile duct
KW - Bilirubin
KW - Cholesterol
KW - Dissolution
KW - Solvents
KW - Stones
UR - http://www.scopus.com/inward/record.url?scp=0029122304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029122304&partnerID=8YFLogxK
M3 - Article
VL - 15
SP - 247
EP - 252
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 5
ER -