Construct validity evaluation of the European Scleroderma Study Group activity index, and investigation of possible new disease activity markers in systemic sclerosis

Tünde Minier, Zoltán Nagy, Zsófia Bálint, Helka Farkas, Judit Radics, Gábor Kumánovics, T. Czömpöly, Diána Simon, Cecília Varjú, P. Németh, L. Czirják

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: To evaluate the construct validity of the European Scleroderma Study Group (EScSG) activity index and to propose modifications if necessary. Methods: One hundred and thirty-one consecutive patients were investigated and re-evaluated 1 year later. Modified Rodnan skin score (MRSS), skin ulcers and joint contracture numbers, hand anatomic index (HAI), BMI, spirometry, carbon monoxide diffusing capacity (DLCO), left ventricular ejection fraction, pulmonary arterial hypertension, HAQ Disability Index (HAQ-DI), patient skin self-assessment questionnaire and several biomarkers were recorded, in addition to the data required for the EScSG activity index. Statistical analysis was performed by categorical principal component analysis (CATPCA). Results: The EScSG activity index appeared in the same dimension as the HAQ-DI, ulcer score and joint contractures, MRSS, patient-reported skin score and HAI by CATPCA. Parameters of lung involvement appeared in another dimension. We constructed a 12-point activity index that was equally associated with both dimensions, by adding the forced vital capacity/DLCO, change in DLCO, change in the ulcer scores, HAQ-DI and patient-reported skin score. Biomarkers including vascular endothelial growth factor, soluble P-selectin glycoprotein ligand-1, CRP and albumin were related to both the EScSG and the 12-point index, though they did not improve the total variance of the model. Conclusion: The construct validity of the EScSG activity index is good, though the lung-related disease activity may not be sufficiently represented. Further validation steps may be required for both the EScSG and our 12-point activity index.

Original languageEnglish
Article numberkeq022
Pages (from-to)1133-1145
Number of pages13
JournalRheumatology
Volume49
Issue number6
DOIs
Publication statusPublished - Mar 17 2010

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ametantrone
Systemic Scleroderma
Skin
Contracture
Principal Component Analysis
Ulcer
Hand
Joints
Biomarkers
Skin Ulcer
Spirometry
Vital Capacity
Carbon Monoxide
Pulmonary Hypertension
Stroke Volume
Vascular Endothelial Growth Factor A
Lung Diseases
Albumins
Lung

Keywords

  • Biomarkers
  • Categorical principal component analysis
  • Disease activity
  • Scleroderma
  • Self-assessment questionnaire
  • Skin ulcers
  • Systemic sclerosis
  • Systemic sclerosis activity index

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Construct validity evaluation of the European Scleroderma Study Group activity index, and investigation of possible new disease activity markers in systemic sclerosis. / Minier, Tünde; Nagy, Zoltán; Bálint, Zsófia; Farkas, Helka; Radics, Judit; Kumánovics, Gábor; Czömpöly, T.; Simon, Diána; Varjú, Cecília; Németh, P.; Czirják, L.

In: Rheumatology, Vol. 49, No. 6, keq022, 17.03.2010, p. 1133-1145.

Research output: Contribution to journalArticle

Minier, Tünde ; Nagy, Zoltán ; Bálint, Zsófia ; Farkas, Helka ; Radics, Judit ; Kumánovics, Gábor ; Czömpöly, T. ; Simon, Diána ; Varjú, Cecília ; Németh, P. ; Czirják, L. / Construct validity evaluation of the European Scleroderma Study Group activity index, and investigation of possible new disease activity markers in systemic sclerosis. In: Rheumatology. 2010 ; Vol. 49, No. 6. pp. 1133-1145.
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AU - Minier, Tünde

AU - Nagy, Zoltán

AU - Bálint, Zsófia

AU - Farkas, Helka

AU - Radics, Judit

AU - Kumánovics, Gábor

AU - Czömpöly, T.

AU - Simon, Diána

AU - Varjú, Cecília

AU - Németh, P.

AU - Czirják, L.

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KW - Self-assessment questionnaire

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