Constitutive nitric oxide modulates the injurious actions of vasopressin on rat intestinal microcirculation in acute endotoxaemia

F. László, Brendan J R Whittle

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The administration of the nitric oxide (NO) synthase inhibitor, NG-nitro-l-arginine methyl ester (L-NAME, 5 mg/kg s.c.) concurrently with Escherichia coli endotoxin (3 mg/kg i.v.) increased vascular permeability and caused mucosal damage in the rat intestine 1 h later. The vasopressin V1 receptor antagonist, [Mca1,Tyr(Me)2,Arg8]vasopressin (0.01-0.2 μg/kg s.c., 15 min before endotoxin) dose-dependently reduced this damage. These results suggest a beneficial role of NO, counteracting the injurious vascular actions of endogenous vasopressin, in maintaining intestinal mucosal integrity in acute endotoxaemic states.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalEuropean Journal of Pharmacology
Volume260
Issue number2-3
DOIs
Publication statusPublished - Aug 1 1994

Fingerprint

Endotoxemia
Microcirculation
Vasopressins
Nitric Oxide
Vasopressin Receptors
NG-Nitroarginine Methyl Ester
Capillary Permeability
Endotoxins
Nitric Oxide Synthase
Intestines
Blood Vessels
Escherichia coli endotoxin
arginine methyl ester
Antidiuretic Hormone Receptor Antagonists

Keywords

  • Endotoxin
  • Intestinal mucosal injury
  • Intestinal vascular permeability
  • N-Nitro-l-arginine methyl ester
  • Nitric oxide (NO)
  • Sepsis
  • Vasopressin
  • Vasopressin receptor antagonist

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Constitutive nitric oxide modulates the injurious actions of vasopressin on rat intestinal microcirculation in acute endotoxaemia. / László, F.; Whittle, Brendan J R.

In: European Journal of Pharmacology, Vol. 260, No. 2-3, 01.08.1994, p. 265-268.

Research output: Contribution to journalArticle

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