Conservation of ribosomal fidelity during ageing

Nozomu Mori, Den'ichi Mizuno, S. Goto

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The function of ribosomes prepared from the liver of young (2-5 months old) and senescent (15-26 months old) mice were compared in vitro. The conclusions that can be drawn from this study are: (1) translational activity of polysomes and purified ribosomes from the liver of senescent mice is 10 to 40% lower than that of young mice; (2) the fidelity of translation does not change grossly with age; (3) the thermosensitivity of translational activity of ribosomes and the activity of ribosome-associated ribonuclease do not change with age; (4) there is an age-dependent accumulation of free 40S ribosomal subunits in the cytoplasm of mouse liver. The relation of age-dependent changes in the structure and function of ribosomes is discussed.

Original languageEnglish
Pages (from-to)379-398
Number of pages20
JournalMechanisms of Ageing and Development
Volume10
Issue number6
DOIs
Publication statusPublished - 1979

Fingerprint

Ribosomes
Liver
Conservation
Aging of materials
Ribonucleases
Eukaryotic Small Ribosome Subunits
Polyribosomes
Cytoplasm

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Conservation of ribosomal fidelity during ageing. / Mori, Nozomu; Mizuno, Den'ichi; Goto, S.

In: Mechanisms of Ageing and Development, Vol. 10, No. 6, 1979, p. 379-398.

Research output: Contribution to journalArticle

Mori, Nozomu ; Mizuno, Den'ichi ; Goto, S. / Conservation of ribosomal fidelity during ageing. In: Mechanisms of Ageing and Development. 1979 ; Vol. 10, No. 6. pp. 379-398.
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