Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis: The SHARE initiative

T. Constantin, Ivan Foeldvari, Jordi Anton, Joke De Boer, Severine Czitrom-Guillaume, Clive Edelsten, Raz Gepstein, Arnd Heiligenhaus, Clarissa A. Pilkington, Gabriele Simonini, Yosef Uziel, Sebastian J. Vastert, Nico M. Wulffraat, Anne Mieke Haasnoot, Karoline Walscheid, Annamária Pálinkás, Reshma Pattani, Zoltán Györgyi, Richárd Kozma, Victor BoomA. Ponyi, Angelo Ravelli, Athimalaipet V. Ramanan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is possibly its most devastating extra-articular manifestation. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment practices differ widely, within and between nations. Objectives: To provide recommendations for the diagnosis and treatment of JIA-associated uveitis. Methods: Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of nine experienced paediatric rheumatologists and three experts in ophthalmology from Europe. Recommendations derived from a validated systematic literature review were evaluated by an Expert Committee and subsequently discussed at two consensus meetings using nominal group techniques. Recommendations were accepted if >80% agreement was reached (including all three ophthalmologists). Results: In total, 22 recommendations were accepted (with >80% agreement among experts): 3 on diagnosis, 5 on disease activity measurements, 12 on treatment and 2 on future recommendations. Conclusions: The SHARE initiative aims to identify best practices for treatment of patients suffering from JIA-associated uveitis. Within this remit, recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated by an evidence-informed consensus process to suggest a standard of care for JIA-associated uveitis patients throughout Europe.

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
DOIs
Publication statusAccepted/In press - Mar 28 2018

Fingerprint

Juvenile Arthritis
Uveitis
Pediatrics
Ophthalmology
Rheumatic Diseases
Therapeutics
Rheumatology
Standard of Care
Practice Guidelines
Young Adult
Joints
Guidelines
Physicians

Keywords

  • juvenile idiopathic arthritis
  • methotrexate
  • Tnf-alpha

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis : The SHARE initiative. / Constantin, T.; Foeldvari, Ivan; Anton, Jordi; De Boer, Joke; Czitrom-Guillaume, Severine; Edelsten, Clive; Gepstein, Raz; Heiligenhaus, Arnd; Pilkington, Clarissa A.; Simonini, Gabriele; Uziel, Yosef; Vastert, Sebastian J.; Wulffraat, Nico M.; Haasnoot, Anne Mieke; Walscheid, Karoline; Pálinkás, Annamária; Pattani, Reshma; Györgyi, Zoltán; Kozma, Richárd; Boom, Victor; Ponyi, A.; Ravelli, Angelo; Ramanan, Athimalaipet V.

In: Annals of the Rheumatic Diseases, 28.03.2018.

Research output: Contribution to journalArticle

Constantin, T, Foeldvari, I, Anton, J, De Boer, J, Czitrom-Guillaume, S, Edelsten, C, Gepstein, R, Heiligenhaus, A, Pilkington, CA, Simonini, G, Uziel, Y, Vastert, SJ, Wulffraat, NM, Haasnoot, AM, Walscheid, K, Pálinkás, A, Pattani, R, Györgyi, Z, Kozma, R, Boom, V, Ponyi, A, Ravelli, A & Ramanan, AV 2018, 'Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis: The SHARE initiative', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2018-213131
Constantin, T. ; Foeldvari, Ivan ; Anton, Jordi ; De Boer, Joke ; Czitrom-Guillaume, Severine ; Edelsten, Clive ; Gepstein, Raz ; Heiligenhaus, Arnd ; Pilkington, Clarissa A. ; Simonini, Gabriele ; Uziel, Yosef ; Vastert, Sebastian J. ; Wulffraat, Nico M. ; Haasnoot, Anne Mieke ; Walscheid, Karoline ; Pálinkás, Annamária ; Pattani, Reshma ; Györgyi, Zoltán ; Kozma, Richárd ; Boom, Victor ; Ponyi, A. ; Ravelli, Angelo ; Ramanan, Athimalaipet V. / Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis : The SHARE initiative. In: Annals of the Rheumatic Diseases. 2018.
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abstract = "Background: In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is possibly its most devastating extra-articular manifestation. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment practices differ widely, within and between nations. Objectives: To provide recommendations for the diagnosis and treatment of JIA-associated uveitis. Methods: Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of nine experienced paediatric rheumatologists and three experts in ophthalmology from Europe. Recommendations derived from a validated systematic literature review were evaluated by an Expert Committee and subsequently discussed at two consensus meetings using nominal group techniques. Recommendations were accepted if >80{\%} agreement was reached (including all three ophthalmologists). Results: In total, 22 recommendations were accepted (with >80{\%} agreement among experts): 3 on diagnosis, 5 on disease activity measurements, 12 on treatment and 2 on future recommendations. Conclusions: The SHARE initiative aims to identify best practices for treatment of patients suffering from JIA-associated uveitis. Within this remit, recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated by an evidence-informed consensus process to suggest a standard of care for JIA-associated uveitis patients throughout Europe.",
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T1 - Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis

T2 - The SHARE initiative

AU - Constantin, T.

AU - Foeldvari, Ivan

AU - Anton, Jordi

AU - De Boer, Joke

AU - Czitrom-Guillaume, Severine

AU - Edelsten, Clive

AU - Gepstein, Raz

AU - Heiligenhaus, Arnd

AU - Pilkington, Clarissa A.

AU - Simonini, Gabriele

AU - Uziel, Yosef

AU - Vastert, Sebastian J.

AU - Wulffraat, Nico M.

AU - Haasnoot, Anne Mieke

AU - Walscheid, Karoline

AU - Pálinkás, Annamária

AU - Pattani, Reshma

AU - Györgyi, Zoltán

AU - Kozma, Richárd

AU - Boom, Victor

AU - Ponyi, A.

AU - Ravelli, Angelo

AU - Ramanan, Athimalaipet V.

PY - 2018/3/28

Y1 - 2018/3/28

N2 - Background: In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is possibly its most devastating extra-articular manifestation. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment practices differ widely, within and between nations. Objectives: To provide recommendations for the diagnosis and treatment of JIA-associated uveitis. Methods: Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of nine experienced paediatric rheumatologists and three experts in ophthalmology from Europe. Recommendations derived from a validated systematic literature review were evaluated by an Expert Committee and subsequently discussed at two consensus meetings using nominal group techniques. Recommendations were accepted if >80% agreement was reached (including all three ophthalmologists). Results: In total, 22 recommendations were accepted (with >80% agreement among experts): 3 on diagnosis, 5 on disease activity measurements, 12 on treatment and 2 on future recommendations. Conclusions: The SHARE initiative aims to identify best practices for treatment of patients suffering from JIA-associated uveitis. Within this remit, recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated by an evidence-informed consensus process to suggest a standard of care for JIA-associated uveitis patients throughout Europe.

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KW - Tnf-alpha

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