Connective tissue metabolism in children with chronic renal failure

László Klujber, Sándor Turi, Ibolya Haszon, Zsuzsa Baranyai, Endre Sulyok

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To assess the characteristics of connective tissue metabolism in chronic renal failure (CRF), urinary excretion of glycosaminoglycan (GAG) fractions and hydroxyproline (HYP) was determined in ten patients with CRF and in ten age-matched healthy children. CRF was found to be associated with elevated free HYP (19.9±6.1 vs 9.8±3.6 μmol/day, P<0.05) and depressed peptide HYP excretion (33.1±13.5 vs 225.2±17.7 μmol/day, P<0.01), a low rate of total GAG excretion (7.0±2.4 vs 16.1±1.9 μmol uronic acid/day, P<0.05) with low chondroitin 4 - sulphate + chondroitin 6 - sulphate (Ch-Ss) (14.0±9.9 vs 65.0±22.1%) and a high proportion of non-sulphated or under-sulphated fractions, i.e. hyaluronic acid + chondroitin + heparan sulphate (HA+Ch+HS) (75.3±11.4 vs 31.5±5.7%). Urinary 3-methyl-histidine (3-met-HIS) excretion and plasma essential free amino acids did not differ in the two groups. In response to haemodialysis no consistent change occurred in urinary excretion of 3-met-HIS, peptide-bound HYP, total GAG or percentage distribution of individual GAG fractions. After haemodialysis all plasma amino acids decreased significantly, and there was a significant increase in urinary excretion of free HYP (P<0.05). We conclude that the alterations in urinary excretion of total and individual GAGs observed in CRF may reflect disturbed connective tissue metabolism which does not appear to be accounted for by protein malnutrition or enhanced protein breakdown and remains uninfluenced by haemodialysis therapy.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalPediatric Nephrology
Volume3
Issue number2
DOIs
Publication statusPublished - Jun 1 1989

Keywords

  • Chronic renal failure
  • Connective tissue metabolism
  • Protein nutrition
  • Urinary glycosaminoglycans

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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