A plazma thromboxan- és prostacyclinszint összefüggése cukorbeteg gyermekek anyagcsere kontrolljával.

Translated title of the contribution: Connection between plasma thromboxane and prostacyclin levels in the metabolic control of diabetic children

L. Orosz, M. Udvardy, P. Vincze, A. Fehér, L. Madácsy

Research output: Contribution to journalReview article

Abstract

Platelet poor plasma thromboxane and prostacyclin levels and the quantity of metabolic control, altogether with vascular complications were evaluated in 55 children diabetes mellitus. The control group consisted of 33 healthy children of the similar age. Thromboxane levels remained unchanged in diabetics, while prostacyclin proved to be significantly decreased, which resulted in greater thromboxane/prostacyclin ratio. No meaningful differences were found according to the presence or absence of vascular complications in this group of diabetics. A positive correlation could have been detected between glycosylated haemoglobin and thromboxane levels, while a negative one between glycosylated haemoglobin and prostacyclin levels. The alterations of prostaglandin metabolism may be regarded as a consequence of diabetic metabolic changes, rather than of vascular complications. Disturbed prostaglandin metabolism in diabetic children might have a role in the pathogenesis of vascular complications.

Translated title of the contributionConnection between plasma thromboxane and prostacyclin levels in the metabolic control of diabetic children
Original languageHungarian
Pages (from-to)125-128
Number of pages4
JournalOrvosi hetilap
Volume130
Issue number3
Publication statusPublished - Jan 15 1989

ASJC Scopus subject areas

  • Medicine(all)

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