Connection between genetically determined blood coagulation factors and haemorheology

Endre Pongrácz, H. Andrikovics, Iván S. Bernát, Zoltán Nagy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The phenotype caracteristic of blood clotting factors are well known, however few data has been documented about effects on haemorheology. The connection among genetic polymorphisms, haemorheological factors and vascular mortality is also studied poorly. Purpose: Our aim was: to study six genetic polymorphisms of blood clotting factors, which presents the role of platelet-plasmaprotein-endothel system in thrombotic course in controls and ischaemic stroke cohort. Second, to study the connection of genotypes and haemorheologic factors and both with five years vascular mortality in patients. Patients and methods: It was studied the genetic polymorhisms of GP IIb/IIIa Leu33Pro, prothrombin gene G20210A, ACE I/D, fibrinogen gene-455 G/A, Leiden mutation and MTHFR C677T alleles or genotypes in blood samples of 433 ischaemic stroke patients and 173 controls by PCR. Haematocrit values, plasma fibrinogen (FIB) concentration, whole blood viscosity (WBV) at 90 s-1 and also the plasma viscosity (PV) were measured. Vascular mortality of patients were followed during five years and studied by curves Kaplan-Meier. Results: A higher plasma FIB concentration in non smoker patients, carrying A alleles of FIB gene could be observed as compared to wild types (p

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume39
Issue number1-4
DOIs
Publication statusPublished - 2008

Fingerprint

Hemorheology
Blood Coagulation Factors
Fibrinogen
Blood Coagulation
Genetic Polymorphisms
Blood Vessels
Mortality
Stroke
Alleles
Genotype
Platelet Membrane Glycoprotein IIb
Genes
Blood Viscosity
Prothrombin
Hematocrit
Viscosity
Blood Platelets
Phenotype
Polymerase Chain Reaction
Mutation

ASJC Scopus subject areas

  • Hematology
  • Physiology

Cite this

Connection between genetically determined blood coagulation factors and haemorheology. / Pongrácz, Endre; Andrikovics, H.; Bernát, Iván S.; Nagy, Zoltán.

In: Clinical Hemorheology and Microcirculation, Vol. 39, No. 1-4, 2008, p. 333-341.

Research output: Contribution to journalArticle

Pongrácz, Endre ; Andrikovics, H. ; Bernát, Iván S. ; Nagy, Zoltán. / Connection between genetically determined blood coagulation factors and haemorheology. In: Clinical Hemorheology and Microcirculation. 2008 ; Vol. 39, No. 1-4. pp. 333-341.
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