Congenital factor XIII deficiency with multiple benign breast tumours and successful pregnancy with substitutive therapy

A case report

Z. Boda, G. Pfliegler, L. Muszbek, A. Tóth, R. Ádány, J. Hársfalvi, Z. Papp, I. Tornai, K. Rak

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5%). The plasmatic level of subunit b was also reduced (25%). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.

Original languageEnglish
Pages (from-to)348-352
Number of pages5
JournalPathophysiology of Haemostasis and Thrombosis
Volume19
Issue number6
DOIs
Publication statusPublished - 1989

Fingerprint

Factor XIII Deficiency
Breast Neoplasms
Factor XIII
Fibroadenoma
Habitual Abortion
Pregnancy
Histiocytes
Connective Tissue
Monocytes
Breast
Blood Platelets
Hemorrhage
Therapeutics
Neoplasms

Keywords

  • Congenital factor XIII deficiency
  • Connective tissue tumour
  • Fresh frozen plasma therapy
  • Habitual abortion
  • Successful pregnancy

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

Cite this

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abstract = "A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5{\%}). The plasmatic level of subunit b was also reduced (25{\%}). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.",
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T1 - Congenital factor XIII deficiency with multiple benign breast tumours and successful pregnancy with substitutive therapy

T2 - A case report

AU - Boda, Z.

AU - Pfliegler, G.

AU - Muszbek, L.

AU - Tóth, A.

AU - Ádány, R.

AU - Hársfalvi, J.

AU - Papp, Z.

AU - Tornai, I.

AU - Rak, K.

PY - 1989

Y1 - 1989

N2 - A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5%). The plasmatic level of subunit b was also reduced (25%). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.

AB - A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5%). The plasmatic level of subunit b was also reduced (25%). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.

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KW - Connective tissue tumour

KW - Fresh frozen plasma therapy

KW - Habitual abortion

KW - Successful pregnancy

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