Congenital Deficiency of Cyclo‐Oxygenase in a Woman with Generalized Atherosclerosis

Z. Boda, E. Tamás, I. Altorjay, G. Pfliegler, K. Rak

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The case of a 52‐year‐old woman with congenital cyclo‐oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet‐rich‐plasma. The life‐long deficiency of cyclo‐oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arterial disorders.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalScandinavian Journal of Haematology
Volume27
Issue number2
DOIs
Publication statusPublished - Aug 1981

Keywords

  • generalized atherosclerosis
  • platelet aggregation
  • platelet cyclo‐oxygenase
  • platelet malondialdehyde production

ASJC Scopus subject areas

  • Hematology

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