Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis

Z. Boda, E. Tamas, I. Altorjay, G. Pfliegler, K. Rak

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The case of a 52-year-old woman with congenital cyclo-oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet-rich-plasma. The life-long deficiency of cyclo-oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arterial disorders.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalScandinavian Journal of Haematology
Volume27
Issue number2
Publication statusPublished - 1981

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Prostaglandin-Endoperoxide Synthases
Platelet Aggregation
Atherosclerosis
Platelet-Rich Plasma
Calcium Ionophores
Malondialdehyde
Vascular Diseases
Arachidonic Acid
Aspirin
Hemorrhage

ASJC Scopus subject areas

  • Hematology

Cite this

Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis. / Boda, Z.; Tamas, E.; Altorjay, I.; Pfliegler, G.; Rak, K.

In: Scandinavian Journal of Haematology, Vol. 27, No. 2, 1981, p. 65-69.

Research output: Contribution to journalArticle

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