Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam

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Abstract

Objective: To evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self-poisoning pregnant women model. Design and setting: Comparative analysis of exposed children and their unexposed sibs born to the same mothers who attempted suicide during the study pregnancy and admitted to the toxicological inpatients clinic, Budapest, 1960-1993. Study participants: Of 1044 pregnant women who attempted suicide, 107 (10.3%) used large doses of nitrazepam alone or combination with other drugs, and 43 delivered live-born babies, these exposed children were evaluated. Main outcomes measures: Structural birth defects, i.e., congenital abnormalities (CAs), pregnancy age at delivery, and birth weight. Results: The mean dose of nitrazepam used for suicide attempt was 204 mg. Of 43 exposed children, 13 (30.2%) were affected with CAs, while of their 29 sib controls, 3 (10.3%) (OR with 95%CI: 3.8, 1.0-14.6). Most CAs in exposed children were mild and belonged to the deformation type. The mean pregnancy age was shorter. Conclusions: The very large doses of nitrazepam used for suicide attempt during pregnancy resulted in a high rate of CAs which may be connected with the disruption of protein metabolism in fetal mesenchyma. The self-poisoning pregnant women model is feasible for the evaluation of teratogenic effect of drugs.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalPharmacoepidemiology and Drug Safety
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Nitrazepam
Attempted Suicide
Pregnant Women
Pregnancy
Poisoning
Suicide
Mesoderm
Birth Weight
Pharmaceutical Preparations
Toxicology
Inpatients
Mothers
Outcome Assessment (Health Care)
Proteins

Keywords

  • Congenital abnormalities
  • Nitrazepam
  • Pregnancy age at delivery
  • Suicide attempt during pregnancy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Epidemiology

Cite this

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title = "Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam",
abstract = "Objective: To evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self-poisoning pregnant women model. Design and setting: Comparative analysis of exposed children and their unexposed sibs born to the same mothers who attempted suicide during the study pregnancy and admitted to the toxicological inpatients clinic, Budapest, 1960-1993. Study participants: Of 1044 pregnant women who attempted suicide, 107 (10.3{\%}) used large doses of nitrazepam alone or combination with other drugs, and 43 delivered live-born babies, these exposed children were evaluated. Main outcomes measures: Structural birth defects, i.e., congenital abnormalities (CAs), pregnancy age at delivery, and birth weight. Results: The mean dose of nitrazepam used for suicide attempt was 204 mg. Of 43 exposed children, 13 (30.2{\%}) were affected with CAs, while of their 29 sib controls, 3 (10.3{\%}) (OR with 95{\%}CI: 3.8, 1.0-14.6). Most CAs in exposed children were mild and belonged to the deformation type. The mean pregnancy age was shorter. Conclusions: The very large doses of nitrazepam used for suicide attempt during pregnancy resulted in a high rate of CAs which may be connected with the disruption of protein metabolism in fetal mesenchyma. The self-poisoning pregnant women model is feasible for the evaluation of teratogenic effect of drugs.",
keywords = "Congenital abnormalities, Nitrazepam, Pregnancy age at delivery, Suicide attempt during pregnancy",
author = "J{\'a}nos Gidai and N. {\'A}cs and F. B{\'a}nhidy and E. Czeizel",
year = "2010",
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T1 - Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam

AU - Gidai, János

AU - Ács, N.

AU - Bánhidy, F.

AU - Czeizel, E.

PY - 2010/2

Y1 - 2010/2

N2 - Objective: To evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self-poisoning pregnant women model. Design and setting: Comparative analysis of exposed children and their unexposed sibs born to the same mothers who attempted suicide during the study pregnancy and admitted to the toxicological inpatients clinic, Budapest, 1960-1993. Study participants: Of 1044 pregnant women who attempted suicide, 107 (10.3%) used large doses of nitrazepam alone or combination with other drugs, and 43 delivered live-born babies, these exposed children were evaluated. Main outcomes measures: Structural birth defects, i.e., congenital abnormalities (CAs), pregnancy age at delivery, and birth weight. Results: The mean dose of nitrazepam used for suicide attempt was 204 mg. Of 43 exposed children, 13 (30.2%) were affected with CAs, while of their 29 sib controls, 3 (10.3%) (OR with 95%CI: 3.8, 1.0-14.6). Most CAs in exposed children were mild and belonged to the deformation type. The mean pregnancy age was shorter. Conclusions: The very large doses of nitrazepam used for suicide attempt during pregnancy resulted in a high rate of CAs which may be connected with the disruption of protein metabolism in fetal mesenchyma. The self-poisoning pregnant women model is feasible for the evaluation of teratogenic effect of drugs.

AB - Objective: To evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self-poisoning pregnant women model. Design and setting: Comparative analysis of exposed children and their unexposed sibs born to the same mothers who attempted suicide during the study pregnancy and admitted to the toxicological inpatients clinic, Budapest, 1960-1993. Study participants: Of 1044 pregnant women who attempted suicide, 107 (10.3%) used large doses of nitrazepam alone or combination with other drugs, and 43 delivered live-born babies, these exposed children were evaluated. Main outcomes measures: Structural birth defects, i.e., congenital abnormalities (CAs), pregnancy age at delivery, and birth weight. Results: The mean dose of nitrazepam used for suicide attempt was 204 mg. Of 43 exposed children, 13 (30.2%) were affected with CAs, while of their 29 sib controls, 3 (10.3%) (OR with 95%CI: 3.8, 1.0-14.6). Most CAs in exposed children were mild and belonged to the deformation type. The mean pregnancy age was shorter. Conclusions: The very large doses of nitrazepam used for suicide attempt during pregnancy resulted in a high rate of CAs which may be connected with the disruption of protein metabolism in fetal mesenchyma. The self-poisoning pregnant women model is feasible for the evaluation of teratogenic effect of drugs.

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KW - Pregnancy age at delivery

KW - Suicide attempt during pregnancy

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