Conformationally constrained adamantaneoxazolines of pharmacological interest

Ioannis Papanastasiou, George B. Foscolos, Andrew Tsotinis, J. Oláh, J. Ovádi, S. Radhika Prathalingam, John M. Kelly

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity.

Original languageEnglish
Pages (from-to)2043-2061
Number of pages19
JournalHeterocycles
Volume75
Issue number8
DOIs
Publication statusPublished - Aug 1 2008

Fingerprint

Adamantane
Tubulin
Polymerization
Pharmacology

Keywords

  • Adamantaneoxazoline
  • Design
  • Synthesis
  • Trypanocidal Action
  • Tubulin Polymerization Inhibition

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

Cite this

Papanastasiou, I., Foscolos, G. B., Tsotinis, A., Oláh, J., Ovádi, J., Radhika Prathalingam, S., & Kelly, J. M. (2008). Conformationally constrained adamantaneoxazolines of pharmacological interest. Heterocycles, 75(8), 2043-2061. https://doi.org/10.3987/COM-08-11377

Conformationally constrained adamantaneoxazolines of pharmacological interest. / Papanastasiou, Ioannis; Foscolos, George B.; Tsotinis, Andrew; Oláh, J.; Ovádi, J.; Radhika Prathalingam, S.; Kelly, John M.

In: Heterocycles, Vol. 75, No. 8, 01.08.2008, p. 2043-2061.

Research output: Contribution to journalArticle

Papanastasiou, I, Foscolos, GB, Tsotinis, A, Oláh, J, Ovádi, J, Radhika Prathalingam, S & Kelly, JM 2008, 'Conformationally constrained adamantaneoxazolines of pharmacological interest', Heterocycles, vol. 75, no. 8, pp. 2043-2061. https://doi.org/10.3987/COM-08-11377
Papanastasiou I, Foscolos GB, Tsotinis A, Oláh J, Ovádi J, Radhika Prathalingam S et al. Conformationally constrained adamantaneoxazolines of pharmacological interest. Heterocycles. 2008 Aug 1;75(8):2043-2061. https://doi.org/10.3987/COM-08-11377
Papanastasiou, Ioannis ; Foscolos, George B. ; Tsotinis, Andrew ; Oláh, J. ; Ovádi, J. ; Radhika Prathalingam, S. ; Kelly, John M. / Conformationally constrained adamantaneoxazolines of pharmacological interest. In: Heterocycles. 2008 ; Vol. 75, No. 8. pp. 2043-2061.
@article{33af847e020c4a88a106f98a5601dd96,
title = "Conformationally constrained adamantaneoxazolines of pharmacological interest",
abstract = "New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity.",
keywords = "Adamantaneoxazoline, Design, Synthesis, Trypanocidal Action, Tubulin Polymerization Inhibition",
author = "Ioannis Papanastasiou and Foscolos, {George B.} and Andrew Tsotinis and J. Ol{\'a}h and J. Ov{\'a}di and {Radhika Prathalingam}, S. and Kelly, {John M.}",
year = "2008",
month = "8",
day = "1",
doi = "10.3987/COM-08-11377",
language = "English",
volume = "75",
pages = "2043--2061",
journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
number = "8",

}

TY - JOUR

T1 - Conformationally constrained adamantaneoxazolines of pharmacological interest

AU - Papanastasiou, Ioannis

AU - Foscolos, George B.

AU - Tsotinis, Andrew

AU - Oláh, J.

AU - Ovádi, J.

AU - Radhika Prathalingam, S.

AU - Kelly, John M.

PY - 2008/8/1

Y1 - 2008/8/1

N2 - New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity.

AB - New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity.

KW - Adamantaneoxazoline

KW - Design

KW - Synthesis

KW - Trypanocidal Action

KW - Tubulin Polymerization Inhibition

UR - http://www.scopus.com/inward/record.url?scp=54249114551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54249114551&partnerID=8YFLogxK

U2 - 10.3987/COM-08-11377

DO - 10.3987/COM-08-11377

M3 - Article

AN - SCOPUS:54249114551

VL - 75

SP - 2043

EP - 2061

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 8

ER -