Conformational and functional properties of peptides covering the intersubunit region of influenza virus hemagglutinin

Miklos HOLLÓSI, Ashraf A. ISMAIL, Henry H. MANTSCH, Botond PENKE, Istvan G. VARADI, Gabor K. TOTH, Ilona LACZKÓ, Istvan KURUCZ, Zoltan NAGY, Gerald D. FASMAN, Eva RAJNAVÖLGYI

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Abstract

The functionally active part of influenza virus hemagglutinin was investigated through the synthesis of a series of peptides representing different parts of the intersubunit region. Secondary structure prediction, circular dichroism and Fourier transform infrared spectroscopic studies were undertaken to investigate the secondary structure of these peptides. The peptide fragments were found to adopt multiple conformations, depending on their concentration in solution, the presence of the non‐ionic detergent octyl‐β‐d‐glucoside and the polarity of the solvent. The results of biological studies with these peptide fragments are discussed in relation to their conformation, as inferred from the spectroscopic analysis.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalEuropean Journal of Biochemistry
Volume206
Issue number2
DOIs
Publication statusPublished - Jun 1992

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ASJC Scopus subject areas

  • Biochemistry

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