Conformational properties of three model pseudo-peptides were investigated by semi-empirical and ab initio MO methods. The three simplest model pseudo-peptides included the protonated form of N-formyl pseudo- alanineamid HCONH-CHMe-CH2NH3+, N-formyl pseudo-alanine itself HCONH-CHMe- CH2NH2, as well as the formylated N-formyl pseudo-alanine (i.e. propylene- di(N-formylamine)) HCONH-CHMe-CH2NHCOH. It was shown that geometries of the pseudo-peptides in their global minima were determined by H-bonds. From the computated results, it follows that in general pseudo-peptides can mimic the backbone of the parent peptides. These computational results are in full agreement with previously reported experimental data. N-formyl pseudo-alanine was shown to be more flexible, than the parent peptide. (C) 2000 Elsevier Science B.V.
- HCONH-CHMe- CHNH
- Semi-empirical and ab initio MO calculations
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry