Conformational analysis of four spiro[cyclohexane-1,3′-indolin]-2′-one derivatives

Judit Halász, Benjamin Podányi, Andrea Sánta-Csutor, Zsolt Böcskei, Kálmán Simon, Miklós Hanusz, István Hermecz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

SR 121463 is a potent and selective, orally active vasopressin V2 receptor antagonist. During the synthesis of SR 121463, the formation of the stereochemistry of the cyclohexyl moiety is one of the most important steps. Conformational analysis (via NMR studies and, for cis-3, also via X-ray structure determination) of the isomers obtained in this step is reported.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalJournal of Molecular Structure
Volume654
Issue number1-3
DOIs
Publication statusPublished - Jun 25 2003

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Keywords

  • Configuration
  • Conformation
  • NMR
  • X-ray diffraction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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