Conformation analysis of intermediates of analogues of Tamoxifen

Rita Kapiller-Dezsofi, Gábor Németh, Györgyi Lax, Gyula Simig, P. Sohár

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The configuration and the conformation of two trifluoromethyl-triaryl-ethane diastereomer pairs and of some sole isomers were determined using the through-space spin-spin coupling between fluorine atoms and the hydrogen of the hydroxyl group. The molecule-mechanical calculations support the results of the conformation-analysis based on the NMR data.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalJournal of Molecular Structure
Volume441
Issue number1
DOIs
Publication statusPublished - Jan 12 1998

Fingerprint

Ethane
spin-spin coupling
Fluorine
Tamoxifen
Hydroxyl Radical
ethane
fluorine
Conformations
Hydrogen
isomers
analogs
nuclear magnetic resonance
hydrogen
configurations
Isomers
atoms
molecules
Nuclear magnetic resonance
Atoms
Molecules

Keywords

  • Conformation analysis
  • Molecule-mechanical calculation
  • NMR spectroscopy
  • Triaryl ethanes (Tamoxifen analogues)

ASJC Scopus subject areas

  • Structural Biology
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Atomic and Molecular Physics, and Optics

Cite this

Conformation analysis of intermediates of analogues of Tamoxifen. / Kapiller-Dezsofi, Rita; Németh, Gábor; Lax, Györgyi; Simig, Gyula; Sohár, P.

In: Journal of Molecular Structure, Vol. 441, No. 1, 12.01.1998, p. 89-92.

Research output: Contribution to journalArticle

Kapiller-Dezsofi, Rita ; Németh, Gábor ; Lax, Györgyi ; Simig, Gyula ; Sohár, P. / Conformation analysis of intermediates of analogues of Tamoxifen. In: Journal of Molecular Structure. 1998 ; Vol. 441, No. 1. pp. 89-92.
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