Conformation analysis of intermediates of analogues of Tamoxifen

Rita Kapiller-Dezsofi, Gábor Németh, Györgyi Lax, Gyula Simig, Pál Sohár

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The configuration and the conformation of two trifluoromethyl-triaryl-ethane diastereomer pairs and of some sole isomers were determined using the through-space spin-spin coupling between fluorine atoms and the hydrogen of the hydroxyl group. The molecule-mechanical calculations support the results of the conformation-analysis based on the NMR data.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalJournal of Molecular Structure
Volume441
Issue number1
DOIs
Publication statusPublished - Jan 12 1998

Keywords

  • Conformation analysis
  • Molecule-mechanical calculation
  • NMR spectroscopy
  • Triaryl ethanes (Tamoxifen analogues)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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