Condensation of interphase chromosomes in nuclei of synchronized CHO cells

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Abstract

The escape of individual interphase chromosomes from nuclei of reversibly permeabilized Chinese hamster ovary (CHO) cells was utilized for the visualization of condensing interphase chromosomes in a cell cycle-dependent manner in synchronized cells. Major interphase chromosomal forms include: (a) mid-S-phase globular chromosomes at 3.0 C-value, (b) late mid-S-phase fibrous hemicircular forms (3.3 C), (c) late-S-phase supercoiled ribbons (3.7 C), and (d) end-S-phase elongated, bent prechromosomal structures (4.0 C).

Original languageEnglish
Pages (from-to)641-645
Number of pages5
JournalDNA and Cell Biology
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 1 2006

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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