Condensation of chromone-3-carboxaldehyde with phenylacetic acids: An efficient synthesis of (E)-3-styrylchromones

Vera L M Silva, Artur M S Silva, Diana C G A Pinto, José A S Cavaleiro, T. Patonay

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An efficient and diastereoselective synthetic method for preparing (E)-3-styrylchromones has been developed by the reaction of chromone-3- carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under classical heating conditions or microwave irradiation. The Knoevenagel-type reaction followed by a decarboxylation was faster under microwave conditions.

Original languageEnglish
Pages (from-to)2717-2720
Number of pages4
JournalSynlett
Issue number15
DOIs
Publication statusPublished - Dec 7 2004

Fingerprint

Phenylacetates
Chromones
Microwave irradiation
Condensation
Microwaves
Heating
potassium tert-butoxide
Decarboxylation

Keywords

  • (E)-3-styrylchromones
  • Chromone-3-carboxaldehyde
  • Condensation
  • Microwave irradiation
  • Phenylacetic acids

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Condensation of chromone-3-carboxaldehyde with phenylacetic acids : An efficient synthesis of (E)-3-styrylchromones. / Silva, Vera L M; Silva, Artur M S; Pinto, Diana C G A; Cavaleiro, José A S; Patonay, T.

In: Synlett, No. 15, 07.12.2004, p. 2717-2720.

Research output: Contribution to journalArticle

Silva, Vera L M ; Silva, Artur M S ; Pinto, Diana C G A ; Cavaleiro, José A S ; Patonay, T. / Condensation of chromone-3-carboxaldehyde with phenylacetic acids : An efficient synthesis of (E)-3-styrylchromones. In: Synlett. 2004 ; No. 15. pp. 2717-2720.
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