Condensation of chromone-3-carboxaldehyde with phenylacetic acids: An efficient synthesis of (E)-3-styrylchromones

Vera L.M. Silva, Artur M.S. Silva, Diana C.G.A. Pinto, José A.S. Cavaleiro, Tamás Patonay

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An efficient and diastereoselective synthetic method for preparing (E)-3-styrylchromones has been developed by the reaction of chromone-3- carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under classical heating conditions or microwave irradiation. The Knoevenagel-type reaction followed by a decarboxylation was faster under microwave conditions.

Original languageEnglish
Pages (from-to)2717-2720
Number of pages4
JournalSynlett
Issue number15
DOIs
Publication statusPublished - Dec 7 2004

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Keywords

  • (E)-3-styrylchromones
  • Chromone-3-carboxaldehyde
  • Condensation
  • Microwave irradiation
  • Phenylacetic acids

ASJC Scopus subject areas

  • Organic Chemistry

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