Concomitant changes of ACTH, β-endorphin and N-terminal portion of pro-opiomelanocortin in rats

M. Lis, N. Larivière, G. Maurice, J. Julesz, N. Seidah, M. Chrétien

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Radioimmunoassay developed to measure N-terminal peptide of pro-opiomelanocortin isolated from porcine pituitaries was used to measure changes in the concentration of immunoreactive material in rat plasma. The N-terminal peptide immunoreactive material decreased in plasma after hypophysectomy of both female and male rats below the level of detectability and substantially increased after adrenalectomy as compared to normal control rats. The same changes were observed when β-endorphin and ACTH like immunoreactive material was measured. The primary culture of rat anterior pituitary cells released ACTH and N-terminal peptide-like immunoreactive material into the incubation medium. The results seem to indicate that the N-terminal immunoreactive material is a secretory product produced by the pituitary gland.

Original languageEnglish
Pages (from-to)1159-1164
Number of pages6
JournalLife Sciences
Volume30
Issue number14
DOIs
Publication statusPublished - Apr 5 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Concomitant changes of ACTH, β-endorphin and N-terminal portion of pro-opiomelanocortin in rats'. Together they form a unique fingerprint.

  • Cite this