Concentrations of elements in brain tumours

Erzsébet Andrási, László Orosz, Henning Scheibler, László Bezúr, László Ernyei

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Abstract

The aim of our experiments was to investigate the possible elemental concentration changes in brain tumours (glioblastoma multiforme). Our project also incorporated the determination of the regional distribution of elements in normal human brains. 17 elements (Na, K, Ca, Mg, Fe, P, S, Al, B, Ba, Co, Cr, Ni, Mn, Pb, Sr, Zn) have been measured in 21 different regions of 20 normal brains and in clinically and histopathologically selected brain regions of patients with brain tumours. Analyses were carried out by instrumental neutron activation analysis (INAA) and inductively coupled plasma atomic emission spectrometry (ICP-AES). Quality control was ensured by using NBS Bovine Liver 1577a standard reference material. Comparison between the healthy and brain tumour concentration data using statistical evaluation revealed only a few elements (e.g. B, Zn, Sr) which showed significant differences as a consequence of the brain tumour.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalMikrochimica Acta
Volume118
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1995

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Keywords

  • ICP-AES
  • INAA
  • brain tumours
  • normal human brain
  • trace elements

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Andrási, E., Orosz, L., Scheibler, H., Bezúr, L., & Ernyei, L. (1995). Concentrations of elements in brain tumours. Mikrochimica Acta, 118(1-2), 113-121. https://doi.org/10.1007/BF01242234