Concentration of biliary metal elements and gallstone formation in humans (cholelithiasis)

K. Szentmihályi, P. Sípos, A. Blázovics, P. Vinkler, M. Szilágyi

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Abstract

Metals in the human body are metabolized mainly via the kidney and liver and excreted through urine and partly by bile. Changes in the composition of bile may induce cholecystitis and cholelithiasis. For the study of the effect of metal elements in the bile on gallstone formation, element concentration in the gallstone (cholesterol and mixed pigment stones) and bile samples were measured. The samples were digested with a mixture of HNO3 (5 ml) and H2O2 (3 ml) in teflon vessels. The concentration of 23 elements (Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Li, Mg, Mn, Mo, Na, Ni, P, S, Ti, V, Zn) in the bile fluid and gallstone samples were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration of Cd, Hg, Li and V in the bile and V in the gallstone samples was below the detection limit in each case. Significant correlation was found between the concentration of Al-Ca (r= 0.985), P-Mg (r= 0.891), S-Mg (r= 0.893) in bile and Al-Ca (r= 0.989), Mn-Ca (r = 0.925), Mn-Al (r = 0.875) in gallstone. On an average, the gallstone/bile concentration ratios of Al, Ca, Cr, Cu and Mn were found to be 120, 164, 190, 165 and 360, respectively, although enrichment in almost all gallstones could be observed only for Al, Ca and Mn. Significant correlation was found between Cr in bile and Al in gallstone (r = 0.901), Cr in bile and Ca in gallstone (r = 0.881), Mn in bile and Ca in gallstone (r = 0.800), Mn in bile and Al in gallstone (r = 0.838). On the basis of the results, a parallel change in the concentration of Al-Ca, P-Mg, S-Mg in bile and Al-Ca, Mn-Ca, Mn-Al in gallstone could be observed. High enrichment was measured for some heavy metals and Ca. The concentration of some elements also influences the gallstone element composition. Mainly, Cr and Mn in bile have an effect on Ca and Al precipitation in gallstone.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalTrace Elements and Electrolytes
Volume19
Issue number3
Publication statusPublished - 2002

Fingerprint

Cholelithiasis
Gallstones
Bile
Metals
Polytetrafluoroethylene
Inductively coupled plasma
Heavy Metals
Chemical analysis
Pigments
Liver
Spectrometry
Cholesterol
Fluids
Bile Pigments
Cholecystitis
Human Body
Limit of Detection
Spectrum Analysis

Keywords

  • Cholelithiasis
  • Elements in bile
  • Elements in gallstone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Concentration of biliary metal elements and gallstone formation in humans (cholelithiasis). / Szentmihályi, K.; Sípos, P.; Blázovics, A.; Vinkler, P.; Szilágyi, M.

In: Trace Elements and Electrolytes, Vol. 19, No. 3, 2002, p. 160-164.

Research output: Contribution to journalArticle

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AU - Sípos, P.

AU - Blázovics, A.

AU - Vinkler, P.

AU - Szilágyi, M.

PY - 2002

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N2 - Metals in the human body are metabolized mainly via the kidney and liver and excreted through urine and partly by bile. Changes in the composition of bile may induce cholecystitis and cholelithiasis. For the study of the effect of metal elements in the bile on gallstone formation, element concentration in the gallstone (cholesterol and mixed pigment stones) and bile samples were measured. The samples were digested with a mixture of HNO3 (5 ml) and H2O2 (3 ml) in teflon vessels. The concentration of 23 elements (Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Li, Mg, Mn, Mo, Na, Ni, P, S, Ti, V, Zn) in the bile fluid and gallstone samples were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration of Cd, Hg, Li and V in the bile and V in the gallstone samples was below the detection limit in each case. Significant correlation was found between the concentration of Al-Ca (r= 0.985), P-Mg (r= 0.891), S-Mg (r= 0.893) in bile and Al-Ca (r= 0.989), Mn-Ca (r = 0.925), Mn-Al (r = 0.875) in gallstone. On an average, the gallstone/bile concentration ratios of Al, Ca, Cr, Cu and Mn were found to be 120, 164, 190, 165 and 360, respectively, although enrichment in almost all gallstones could be observed only for Al, Ca and Mn. Significant correlation was found between Cr in bile and Al in gallstone (r = 0.901), Cr in bile and Ca in gallstone (r = 0.881), Mn in bile and Ca in gallstone (r = 0.800), Mn in bile and Al in gallstone (r = 0.838). On the basis of the results, a parallel change in the concentration of Al-Ca, P-Mg, S-Mg in bile and Al-Ca, Mn-Ca, Mn-Al in gallstone could be observed. High enrichment was measured for some heavy metals and Ca. The concentration of some elements also influences the gallstone element composition. Mainly, Cr and Mn in bile have an effect on Ca and Al precipitation in gallstone.

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