Concentration-dependent effect of met-enkephalin on human polymorphonuclear leukocytes

G. Foris, G. A. Medgyesi, J. T. Nagy, Z. Varga

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21 Citations (Scopus)

Abstract

Met-enkephalin in 10-9-10-7 M concentrations exerts an ADCC-stimulating effect on human PMNLs through naloxone-sensitive opiate receptors, elevating the cytoplasmic free Ca2+ and cGMP levels. In higher, 10-6-10-5 M concentrations ME has a cAMP-elevating effect and a rapid 45Ca2+ influx was observed. This latter effect of ME, which is also associated with the suppression of ADCC activity, was abolished by the enkephalinase inhibitor, puromycin. A strong relationship is suggested between the suppressing effect of met-enkephalin, enkaphalinase and the protein kinase C system.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume496
Publication statusPublished - 1987

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Antibody-Dependent Cell Cytotoxicity
Methionine Enkephalin
Neutrophils
Neprilysin
Puromycin
Opioid Receptors
Naloxone
Protein Kinase C

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Concentration-dependent effect of met-enkephalin on human polymorphonuclear leukocytes. / Foris, G.; Medgyesi, G. A.; Nagy, J. T.; Varga, Z.

In: Annals of the New York Academy of Sciences, Vol. 496, 1987, p. 151-157.

Research output: Contribution to journalArticle

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