Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats

E. Tátrai, G. Ungváry, A. Hudák, K. Rodics, M. Lörincz, G. Barcza

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

CFY rats were exposed to continuous benzene inhalation 24 hr/day from day 7 to day 14 of gestation at 150, 450, 1500, or 3000 mg/m3 (50, 150, 500, or 1000 ppm) atmospheric concentrations. None of the benzene concentrations used proved to be teratogenic. There was no increase in the incidence of external, visceral, or skeletal malformations. Benzene inhalation at a 150 mg/m3 concentration brought about a slight toxic effect; at a 450 mg/m3 concentration, a more pronounced effect on both mothers and fetuses was seen. The toxic effects were manifest as an increase in maternal mortality, circulatory damage, decreased gain in body weight, decrease in the weight of the placenta in the mothers and an increase in mortality (early and late), and retardation of development (weight and skeleton) in the fetuses. No further change in the parameters was seen with further increases in benzene concentration. Avoidance of the risks of benzene exposure seems desirable before the commencement of planned pregnancy in the human.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalJournal of Hygiene Epidemiology Microbiology and Immunology
Volume24
Issue number3
Publication statusPublished - 1980

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Benzene
Inhalation
Poisons
Fetus
Weights and Measures
Maternal Mortality
Family Planning Services
Skeleton
Placenta
Body Weight
Pregnancy
Mortality
Incidence

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Immunology

Cite this

Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats. / Tátrai, E.; Ungváry, G.; Hudák, A.; Rodics, K.; Lörincz, M.; Barcza, G.

In: Journal of Hygiene Epidemiology Microbiology and Immunology, Vol. 24, No. 3, 1980, p. 363-371.

Research output: Contribution to journalArticle

Tátrai, E. ; Ungváry, G. ; Hudák, A. ; Rodics, K. ; Lörincz, M. ; Barcza, G. / Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats. In: Journal of Hygiene Epidemiology Microbiology and Immunology. 1980 ; Vol. 24, No. 3. pp. 363-371.
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