Computer control of pH and DO in a laboratory fermenter using a neural network technique

A. Mészáros, A. Andrášik, P. Mizsey, Z. Fonyó, V. Illeová

Research output: Contribution to journalArticle

10 Citations (Scopus)


In this contribution, the advantages of the artificial neural network approach to the identification and control of a laboratory-scale biochemical reactor are demonstrated. It is very important to be able to maintain the levels of two process variables, pH and dissolved oxygen (DO) concentration, over the course of fermentation in biosystems control. A PC-supported, fully automated, multi-task control system has been designed and built by the authors. Forward and inverse neural process models are used to identify and control both the pH and the DO concentration in a fermenter containing a Saccharomyces cerevisiae based-culture. The models are trained off-line, using a modified back-propagation algorithm based on conjugate gradients. The inverse neural controller is augmented by a new adaptive term that results in a system with robust performance. Experimental results have confirmed that the regulatory and tracking performances of the control system proposed are good.

Original languageEnglish
Pages (from-to)331-340
Number of pages10
JournalBioprocess and Biosystems Engineering
Issue number5
Publication statusPublished - Oct 1 2004


  • Control system
  • Laboratory fermenter
  • Neural networks

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Fingerprint Dive into the research topics of 'Computer control of pH and DO in a laboratory fermenter using a neural network technique'. Together they form a unique fingerprint.

  • Cite this