Computer analysis of the hippocampal electrical activity

effects of hypothalamic stimulation in the rat

G. Karmos, W. Kent

Research output: Contribution to journalArticle

Abstract

The behavioral reactions and the electrical activity of the dorsal hippocampus were studied in freely moving rats during high frequency stimulation of the hypothalamus. The frequency and amplitude changes of the hippocampal EEG activity induced by different intensity stimuli were quantitatively analysed by power spectrum analysis. Threshold intensity hypothalamic stimulation elicited in most of the cases regular slow wave activity (RSA), the frequency of which increased proportional to the stimulus intensity. With a stepwise increase of the stimulus intensity the amplitude of the RSA first increased while higher intensities elicited a decrease in the EEG amplitude. Highest intensities induced clear desynchronization in the hippocampus. Usually intensive running behavior appeared during the stimulation eliciting this electrical pattern. The observed frequency-amplitude changes suggest that at hypothalamic stimulation the input into the hippocampus influences primarily the frequency of the electrical activity while the amplitude depends on the inert characteristics of the hippocampal neuronal circuitry.

Original languageEnglish
JournalElectroencephalography and Clinical Neurophysiology
Volume43
Issue number4
Publication statusPublished - 1977

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Hippocampus
Electroencephalography
Running
Electric Stimulation
Hypothalamus
Spectrum Analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

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AB - The behavioral reactions and the electrical activity of the dorsal hippocampus were studied in freely moving rats during high frequency stimulation of the hypothalamus. The frequency and amplitude changes of the hippocampal EEG activity induced by different intensity stimuli were quantitatively analysed by power spectrum analysis. Threshold intensity hypothalamic stimulation elicited in most of the cases regular slow wave activity (RSA), the frequency of which increased proportional to the stimulus intensity. With a stepwise increase of the stimulus intensity the amplitude of the RSA first increased while higher intensities elicited a decrease in the EEG amplitude. Highest intensities induced clear desynchronization in the hippocampus. Usually intensive running behavior appeared during the stimulation eliciting this electrical pattern. The observed frequency-amplitude changes suggest that at hypothalamic stimulation the input into the hippocampus influences primarily the frequency of the electrical activity while the amplitude depends on the inert characteristics of the hippocampal neuronal circuitry.

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