Triplex forming oligonucleotides could prevent genetic transcription at the level of genes. Nucleotide bases with the capability of specific H- bonding interactions with base pairs in the major groove of DNA have been designed. Calculations by semiempirical methods lead to four compounds as possible triplet forming nucleobases.
|Number of pages||3|
|Journal||Nucleosides and Nucleotides|
|Publication status||Published - Jan 1 1999|
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