Computer aided design of triplet forming artificial nucleobases

R. Fenyõ, Z. Timár, I. Pálinkó, B. Penke

Research output: Contribution to journalArticle

Abstract

Triplex forming oligonucleotides could prevent genetic transcription at the level of genes. Nucleotide bases with the capability of specific H- bonding interactions with base pairs in the major groove of DNA have been designed. Calculations by semiempirical methods lead to four compounds as possible triplet forming nucleobases.

Original languageEnglish
Pages (from-to)1127-1129
Number of pages3
JournalNucleosides and Nucleotides
Volume18
Issue number4-5
Publication statusPublished - Jan 1 1999

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ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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