Computational approach to schizophrenia: Disconnection syndrome and dynamical pharmacology

Péter Érdi, Brad Flaugher, Trevor Jones, Balázs Ujfalussy, László Zalányi, Vaibhav A. Diwadkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Schizophrenia may be best understood in terms of abnormal interactions between different brain regions. Tasks such as associative learning that engage different brain regions may be ideal for studying altered brain function in the illness. Preliminary data suggest that the hippocampus is involved in the encoding (learning) and the prefrontal cortex in the retrieval of associative memories. Specific changes in the fMRI activities have also been observed based on comparative studies between stable schizophrenia patients and healthy control subjects. Disconnectivity, observed between brain regions in schizophrenic patients could result from abnormal modulation of N-methyl-D-aspartate (NMDA)-dependent plasticity implicated in schizophrenia.

Original languageEnglish
Title of host publicationCollective Dynamics
Subtitle of host publicationTopics on Competition and Cooperation in the Biosciences - A selection of papers in the Proceedings of the BIOCOMP2007 International Conference
Pages65-87
Number of pages23
DOIs
Publication statusPublished - Sep 11 2008
EventInternational Conference on Collective Dynamics: Topics on Competition and Cooperation in the Biosciences, BIOCOMP2007 - Vietri sul Mare, Italy
Duration: Nov 24 2007Nov 29 2007

Publication series

NameAIP Conference Proceedings
Volume1028
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherInternational Conference on Collective Dynamics: Topics on Competition and Cooperation in the Biosciences, BIOCOMP2007
CountryItaly
CityVietri sul Mare
Period11/24/0711/29/07

Keywords

  • Associative learning
  • Dynamical diseases
  • Schizophrenia models

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Érdi, P., Flaugher, B., Jones, T., Ujfalussy, B., Zalányi, L., & Diwadkar, V. A. (2008). Computational approach to schizophrenia: Disconnection syndrome and dynamical pharmacology. In Collective Dynamics: Topics on Competition and Cooperation in the Biosciences - A selection of papers in the Proceedings of the BIOCOMP2007 International Conference (pp. 65-87). (AIP Conference Proceedings; Vol. 1028). https://doi.org/10.1063/1.2965102