Computational approach to schizophrenia: Disconnection syndrome and dynamical pharmacology

P. Érdi, Brad Flaugher, Trevor Jones, Balázs Ujfalussy, László Zalányi, Vaibhav A. Diwadkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Schizophrenia may be best understood in terms of abnormal interactions between different brain regions. Tasks such as associative learning that engage different brain regions may be ideal for studying altered brain function in the illness. Preliminary data suggest that the hippocampus is involved in the encoding (learning) and the prefrontal cortex in the retrieval of associative memories. Specific changes in the fMRI activities have also been observed based on comparative studies between stable schizophrenia patients and healthy control subjects. Disconnectivity, observed between brain regions in schizophrenic patients could result from abnormal modulation of N-methyl-D-aspartate (NMDA)-dependent plasticity implicated in schizophrenia.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages65-87
Number of pages23
Volume1028
DOIs
Publication statusPublished - 2008
EventInternational Conference on Collective Dynamics: Topics on Competition and Cooperation in the Biosciences, BIOCOMP2007 - Vietri sul Mare, Italy
Duration: Nov 24 2007Nov 29 2007

Other

OtherInternational Conference on Collective Dynamics: Topics on Competition and Cooperation in the Biosciences, BIOCOMP2007
CountryItaly
CityVietri sul Mare
Period11/24/0711/29/07

Fingerprint

pharmacology
schizophrenia
brain
learning
hippocampus
aspartates
associative memory
cortexes
plastic properties
retrieval
coding
modulation
interactions

Keywords

  • Associative learning
  • Dynamical diseases
  • Schizophrenia models

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Érdi, P., Flaugher, B., Jones, T., Ujfalussy, B., Zalányi, L., & Diwadkar, V. A. (2008). Computational approach to schizophrenia: Disconnection syndrome and dynamical pharmacology. In AIP Conference Proceedings (Vol. 1028, pp. 65-87) https://doi.org/10.1063/1.2965102

Computational approach to schizophrenia : Disconnection syndrome and dynamical pharmacology. / Érdi, P.; Flaugher, Brad; Jones, Trevor; Ujfalussy, Balázs; Zalányi, László; Diwadkar, Vaibhav A.

AIP Conference Proceedings. Vol. 1028 2008. p. 65-87.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Érdi, P, Flaugher, B, Jones, T, Ujfalussy, B, Zalányi, L & Diwadkar, VA 2008, Computational approach to schizophrenia: Disconnection syndrome and dynamical pharmacology. in AIP Conference Proceedings. vol. 1028, pp. 65-87, International Conference on Collective Dynamics: Topics on Competition and Cooperation in the Biosciences, BIOCOMP2007, Vietri sul Mare, Italy, 11/24/07. https://doi.org/10.1063/1.2965102
Érdi P, Flaugher B, Jones T, Ujfalussy B, Zalányi L, Diwadkar VA. Computational approach to schizophrenia: Disconnection syndrome and dynamical pharmacology. In AIP Conference Proceedings. Vol. 1028. 2008. p. 65-87 https://doi.org/10.1063/1.2965102
Érdi, P. ; Flaugher, Brad ; Jones, Trevor ; Ujfalussy, Balázs ; Zalányi, László ; Diwadkar, Vaibhav A. / Computational approach to schizophrenia : Disconnection syndrome and dynamical pharmacology. AIP Conference Proceedings. Vol. 1028 2008. pp. 65-87
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