Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations

I. Balásházy, W. Hofmann, T. Heistracher

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Spatial deposition patterns in two different geometric models of bronchial airway bifurcations were computed by solving numerically the 3D Navier-Stokes equations and simulating particle trajectories under the simultaneous action of impaction, sedimentation, diffusion, and interception by Monte Carlo techniques. To quantify the inhomogeneities of the predicted deposition patterns the whole surface of the bifurcation was scanned with a prespecified surface area element to determine the number of particles deposited per unit surface area. The local deposition density in a given surface element, relative to the average deposition density, was then defined as the local deposition enhancement factor. In the present study, the computation of local deposition enhancement factors focused on inspiratory particle deposition patterns. Our results revealed that the distributions of local deposition enhancement factors along the surface of a bifurcation exhibit strong inhomogeneities for all particle sizes and bifurcation geometries considered here. The maximum enhancement factor in a bifurcation was found to be about 100 in the upper bronchial airways for any particle size in the diameter range from 0.01 to 10 μm, obtained with a 100 μm x 100 μm scanning element. These numerically computed local deposition enhancement factors can be directly applied to inhalation health effect protocols to consider the effects of highly localized doses.

Original languageEnglish
Pages (from-to)185-203
Number of pages19
JournalJournal of Aerosol Science
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 1 1999

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bifurcation
inhomogeneity
surface area
Particle size
particle size
particle
Bifurcation (mathematics)
Navier-Stokes equations
interception
Sedimentation
Navier Stokes equations
trajectory
Trajectories
Health
sedimentation
Scanning
geometry
Geometry

ASJC Scopus subject areas

  • Atmospheric Science
  • Environmental Science(all)

Cite this

Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations. / Balásházy, I.; Hofmann, W.; Heistracher, T.

In: Journal of Aerosol Science, Vol. 30, No. 2, 01.02.1999, p. 185-203.

Research output: Contribution to journalArticle

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