Szomatikus onkogén mutációk összehasonlí tó vizsgálata egészséges és tumoros pajzsmirigy-szövetmintákban

Translated title of the contribution: Comprehensive examination of somatic oncogene mutation in normal and pathologic thyroid tissues

Bálint Tóbiás, Bernadett Balla, János Kósa P., János Horányi, István Takács, Eszter Bölöny, Csaba Halászlaki, Zsolt Nagy, Gábor Speer, Balázs Járay, Eszter Székely, Roland Istók, Péter Lakatos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It is established that numerous somatic oncogene mutation (BRAF, NRAS, HRAS, KRAS) and gene translocations (RET/PTC, PAX8/PPAR-gamma) are associated with the development of thyroid cancer. In this study 22 intraoperative thyroid tissue samples (11 pathologic and 11 normal) were examined. Somatic single nucleotide polymorphisms were analyzed by LigthCycler melting method, while translocations were identified by real-time polymerase chain reaction technique. In tumorous sample 3 BRAF, 2 NRAS and one HRAS mutations were found, as well as one RET/PTC1 translocation. Results confirm international data showing that these oncogene mutations and translocations are linked to thyroid cancer. Cytological examination completed with genetic data may support the diagnosis of thyroid malignancies. In addition, genetic alterations may indicate malignant transformation and may become prognostic factors in future.

Original languageHungarian
Pages (from-to)672-677
Number of pages6
JournalOrvosi hetilap
Volume152
Issue number17
DOIs
Publication statusPublished - Apr 1 2011

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tóbiás, B., Balla, B., Kósa P., J., Horányi, J., Takács, I., Bölöny, E., Halászlaki, C., Nagy, Z., Speer, G., Járay, B., Székely, E., Istók, R., & Lakatos, P. (2011). Szomatikus onkogén mutációk összehasonlí tó vizsgálata egészséges és tumoros pajzsmirigy-szövetmintákban. Orvosi hetilap, 152(17), 672-677. https://doi.org/10.1556/OH.2011.29097