Szomatikus onkogén mutációk összehasonlí tó vizsgálata egészséges és tumoros pajzsmirigy-szövetmintákban

Translated title of the contribution: Comprehensive examination of somatic oncogene mutation in normal and pathologic thyroid tissues

Bálint Tóbiás, Bernadett Balla, János Kósa P., János Horányi, I. Takács, Eszter Bölöny, Csaba Halászlaki, Zsolt Nagy, G. Speer, Balázs Járay, Eszter Székely, Roland Istók, P. Lakatos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It is established that numerous somatic oncogene mutation (BRAF, NRAS, HRAS, KRAS) and gene translocations (RET/PTC, PAX8/PPAR-gamma) are associated with the development of thyroid cancer. In this study 22 intraoperative thyroid tissue samples (11 pathologic and 11 normal) were examined. Somatic single nucleotide polymorphisms were analyzed by LigthCycler melting method, while translocations were identified by real-time polymerase chain reaction technique. In tumorous sample 3 BRAF, 2 NRAS and one HRAS mutations were found, as well as one RET/PTC1 translocation. Results confirm international data showing that these oncogene mutations and translocations are linked to thyroid cancer. Cytological examination completed with genetic data may support the diagnosis of thyroid malignancies. In addition, genetic alterations may indicate malignant transformation and may become prognostic factors in future.

Original languageHungarian
Pages (from-to)672-677
Number of pages6
JournalOrvosi Hetilap
Volume152
Issue number17
DOIs
Publication statusPublished - Apr 1 2011

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Oncogenes
Thyroid Gland
Thyroid Neoplasms
Mutation
Factor IX
PPAR gamma
Freezing
Single Nucleotide Polymorphism
Real-Time Polymerase Chain Reaction
Genes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szomatikus onkogén mutációk összehasonlí tó vizsgálata egészséges és tumoros pajzsmirigy-szövetmintákban. / Tóbiás, Bálint; Balla, Bernadett; Kósa P., János; Horányi, János; Takács, I.; Bölöny, Eszter; Halászlaki, Csaba; Nagy, Zsolt; Speer, G.; Járay, Balázs; Székely, Eszter; Istók, Roland; Lakatos, P.

In: Orvosi Hetilap, Vol. 152, No. 17, 01.04.2011, p. 672-677.

Research output: Contribution to journalArticle

Tóbiás, B, Balla, B, Kósa P., J, Horányi, J, Takács, I, Bölöny, E, Halászlaki, C, Nagy, Z, Speer, G, Járay, B, Székely, E, Istók, R & Lakatos, P 2011, 'Szomatikus onkogén mutációk összehasonlí tó vizsgálata egészséges és tumoros pajzsmirigy-szövetmintákban', Orvosi Hetilap, vol. 152, no. 17, pp. 672-677. https://doi.org/10.1556/OH.2011.29097
Tóbiás, Bálint ; Balla, Bernadett ; Kósa P., János ; Horányi, János ; Takács, I. ; Bölöny, Eszter ; Halászlaki, Csaba ; Nagy, Zsolt ; Speer, G. ; Járay, Balázs ; Székely, Eszter ; Istók, Roland ; Lakatos, P. / Szomatikus onkogén mutációk összehasonlí tó vizsgálata egészséges és tumoros pajzsmirigy-szövetmintákban. In: Orvosi Hetilap. 2011 ; Vol. 152, No. 17. pp. 672-677.
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