Comprehensive coronary plaque assessment in patients with obstructive sleep apnea

Andras Bikov, Márton Kolossváry, Adam L. Jermendy, Zsofia D. Drobni, Adam D. Tarnoki, David L. Tarnoki, Bianka Forgó, Daniel T. Kovacs, Gyorgy Losonczy, Laszlo Kunos, Szilard Voros, B. Merkely, Pal Maurovich-Horvat

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using coronary artery calcium score (CAC) measurements. However, limited data are available regarding the association of OSA with non-calcified plaque burden. We therefore aimed to assess the relationship between CAD severity as assessed by coronary computed tomography angiography (CTA) and OSA. Forty-one adult subjects (59 ± 9 years, 15 men) underwent a 256-slice coronary CTA, which was followed by a diagnostic attended cardiorespiratory polygraphy (n = 13) or polysomnography (n = 28). Segment involvement score (SIS), segment stenosis score (SSS) and CAC were used to quantify total CAD burden. Correlation analysis was used to assess potential associations between CAD and OSA. Twenty-two patients were diagnosed with OSA. SIS and SSS were elevated in OSA (2.90 ± 2.78 versus 1.79 ± 2.39 and 4.91 ± 5.94 versus 1.79 ± 4.54, OSA versus controls, SIS and SSS respectively, both p < 0.01) and correlated with OSA severity as measured by the apnea-hypopnea index (AHI, r = 0.41 and 0.43, p < 0.01) and oxygen desaturation index (ODI, r = 0.45 and 0.46, p < 0.01). However, no significant correlation was observed between CAC and OSA. Compared to CAC, SIS and SSS provide additional information on coronary plaque burden in OSA, which shows a significant association with OSA.

Original languageEnglish
Article numbere12828
JournalJournal of Sleep Research
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Obstructive Sleep Apnea
Coronary Artery Disease
Calcium
Coronary Vessels
Pathologic Constriction
Polysomnography
Coronary Stenosis
Apnea
Cardiovascular Diseases
Oxygen

Keywords

  • coronary artery calcium
  • coronary artery disease
  • coronary CT angiography
  • segment involvement score
  • segment stenosis score
  • sleep apnea

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Bikov, A., Kolossváry, M., Jermendy, A. L., Drobni, Z. D., Tarnoki, A. D., Tarnoki, D. L., ... Maurovich-Horvat, P. (2019). Comprehensive coronary plaque assessment in patients with obstructive sleep apnea. Journal of Sleep Research, [e12828]. https://doi.org/10.1111/jsr.12828

Comprehensive coronary plaque assessment in patients with obstructive sleep apnea. / Bikov, Andras; Kolossváry, Márton; Jermendy, Adam L.; Drobni, Zsofia D.; Tarnoki, Adam D.; Tarnoki, David L.; Forgó, Bianka; Kovacs, Daniel T.; Losonczy, Gyorgy; Kunos, Laszlo; Voros, Szilard; Merkely, B.; Maurovich-Horvat, Pal.

In: Journal of Sleep Research, 01.01.2019.

Research output: Contribution to journalArticle

Bikov, A, Kolossváry, M, Jermendy, AL, Drobni, ZD, Tarnoki, AD, Tarnoki, DL, Forgó, B, Kovacs, DT, Losonczy, G, Kunos, L, Voros, S, Merkely, B & Maurovich-Horvat, P 2019, 'Comprehensive coronary plaque assessment in patients with obstructive sleep apnea', Journal of Sleep Research. https://doi.org/10.1111/jsr.12828
Bikov A, Kolossváry M, Jermendy AL, Drobni ZD, Tarnoki AD, Tarnoki DL et al. Comprehensive coronary plaque assessment in patients with obstructive sleep apnea. Journal of Sleep Research. 2019 Jan 1. e12828. https://doi.org/10.1111/jsr.12828
Bikov, Andras ; Kolossváry, Márton ; Jermendy, Adam L. ; Drobni, Zsofia D. ; Tarnoki, Adam D. ; Tarnoki, David L. ; Forgó, Bianka ; Kovacs, Daniel T. ; Losonczy, Gyorgy ; Kunos, Laszlo ; Voros, Szilard ; Merkely, B. ; Maurovich-Horvat, Pal. / Comprehensive coronary plaque assessment in patients with obstructive sleep apnea. In: Journal of Sleep Research. 2019.
@article{7b1960f29f454f838565800bfc8b2145,
title = "Comprehensive coronary plaque assessment in patients with obstructive sleep apnea",
abstract = "Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using coronary artery calcium score (CAC) measurements. However, limited data are available regarding the association of OSA with non-calcified plaque burden. We therefore aimed to assess the relationship between CAD severity as assessed by coronary computed tomography angiography (CTA) and OSA. Forty-one adult subjects (59 ± 9 years, 15 men) underwent a 256-slice coronary CTA, which was followed by a diagnostic attended cardiorespiratory polygraphy (n = 13) or polysomnography (n = 28). Segment involvement score (SIS), segment stenosis score (SSS) and CAC were used to quantify total CAD burden. Correlation analysis was used to assess potential associations between CAD and OSA. Twenty-two patients were diagnosed with OSA. SIS and SSS were elevated in OSA (2.90 ± 2.78 versus 1.79 ± 2.39 and 4.91 ± 5.94 versus 1.79 ± 4.54, OSA versus controls, SIS and SSS respectively, both p < 0.01) and correlated with OSA severity as measured by the apnea-hypopnea index (AHI, r = 0.41 and 0.43, p < 0.01) and oxygen desaturation index (ODI, r = 0.45 and 0.46, p < 0.01). However, no significant correlation was observed between CAC and OSA. Compared to CAC, SIS and SSS provide additional information on coronary plaque burden in OSA, which shows a significant association with OSA.",
keywords = "coronary artery calcium, coronary artery disease, coronary CT angiography, segment involvement score, segment stenosis score, sleep apnea",
author = "Andras Bikov and M{\'a}rton Kolossv{\'a}ry and Jermendy, {Adam L.} and Drobni, {Zsofia D.} and Tarnoki, {Adam D.} and Tarnoki, {David L.} and Bianka Forg{\'o} and Kovacs, {Daniel T.} and Gyorgy Losonczy and Laszlo Kunos and Szilard Voros and B. Merkely and Pal Maurovich-Horvat",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/jsr.12828",
language = "English",
journal = "Journal of Sleep Research",
issn = "0962-1105",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Comprehensive coronary plaque assessment in patients with obstructive sleep apnea

AU - Bikov, Andras

AU - Kolossváry, Márton

AU - Jermendy, Adam L.

AU - Drobni, Zsofia D.

AU - Tarnoki, Adam D.

AU - Tarnoki, David L.

AU - Forgó, Bianka

AU - Kovacs, Daniel T.

AU - Losonczy, Gyorgy

AU - Kunos, Laszlo

AU - Voros, Szilard

AU - Merkely, B.

AU - Maurovich-Horvat, Pal

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using coronary artery calcium score (CAC) measurements. However, limited data are available regarding the association of OSA with non-calcified plaque burden. We therefore aimed to assess the relationship between CAD severity as assessed by coronary computed tomography angiography (CTA) and OSA. Forty-one adult subjects (59 ± 9 years, 15 men) underwent a 256-slice coronary CTA, which was followed by a diagnostic attended cardiorespiratory polygraphy (n = 13) or polysomnography (n = 28). Segment involvement score (SIS), segment stenosis score (SSS) and CAC were used to quantify total CAD burden. Correlation analysis was used to assess potential associations between CAD and OSA. Twenty-two patients were diagnosed with OSA. SIS and SSS were elevated in OSA (2.90 ± 2.78 versus 1.79 ± 2.39 and 4.91 ± 5.94 versus 1.79 ± 4.54, OSA versus controls, SIS and SSS respectively, both p < 0.01) and correlated with OSA severity as measured by the apnea-hypopnea index (AHI, r = 0.41 and 0.43, p < 0.01) and oxygen desaturation index (ODI, r = 0.45 and 0.46, p < 0.01). However, no significant correlation was observed between CAC and OSA. Compared to CAC, SIS and SSS provide additional information on coronary plaque burden in OSA, which shows a significant association with OSA.

AB - Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using coronary artery calcium score (CAC) measurements. However, limited data are available regarding the association of OSA with non-calcified plaque burden. We therefore aimed to assess the relationship between CAD severity as assessed by coronary computed tomography angiography (CTA) and OSA. Forty-one adult subjects (59 ± 9 years, 15 men) underwent a 256-slice coronary CTA, which was followed by a diagnostic attended cardiorespiratory polygraphy (n = 13) or polysomnography (n = 28). Segment involvement score (SIS), segment stenosis score (SSS) and CAC were used to quantify total CAD burden. Correlation analysis was used to assess potential associations between CAD and OSA. Twenty-two patients were diagnosed with OSA. SIS and SSS were elevated in OSA (2.90 ± 2.78 versus 1.79 ± 2.39 and 4.91 ± 5.94 versus 1.79 ± 4.54, OSA versus controls, SIS and SSS respectively, both p < 0.01) and correlated with OSA severity as measured by the apnea-hypopnea index (AHI, r = 0.41 and 0.43, p < 0.01) and oxygen desaturation index (ODI, r = 0.45 and 0.46, p < 0.01). However, no significant correlation was observed between CAC and OSA. Compared to CAC, SIS and SSS provide additional information on coronary plaque burden in OSA, which shows a significant association with OSA.

KW - coronary artery calcium

KW - coronary artery disease

KW - coronary CT angiography

KW - segment involvement score

KW - segment stenosis score

KW - sleep apnea

UR - http://www.scopus.com/inward/record.url?scp=85061175911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061175911&partnerID=8YFLogxK

U2 - 10.1111/jsr.12828

DO - 10.1111/jsr.12828

M3 - Article

AN - SCOPUS:85061175911

JO - Journal of Sleep Research

JF - Journal of Sleep Research

SN - 0962-1105

M1 - e12828

ER -