Az EOB-DTPA ligandum komplexképzo sajátságai és a Gd(EOB-DTPA)2- kinetikai stabilitása

Translated title of the contribution: Complexation properties of the ligand EOB-DTPA and the kinetic stability of Gd(EOB-DTPA)2-

L. Burai, E. Brücher, R. Király, P. Solymosi, T. Víg

Research output: Contribution to journalArticle

5 Citations (Scopus)


Due to the presence of the ethoxy-benzyl group, the lipophilicity of the complex Gd(EOB-DTPA)2- is higher than that of Gd(DTPA)2- and thus Gd(EOB-DTPA)2- can be used as a liver specific contrast agent in Magnetic Resonance Imaging. The stability constants of the complexes of Fe2+, Fe3+, Zn2+ and Cu2+ formed with EOB-DTPA practically agree with those of the respective DTPA complexes. The complexes of EOB-DTPA formed with larger metal ions, like Ca2+, Ba2+, Gd3+ and other lanthanides, exhibit larger stability constants than the complexes of DTPA by 0.5-1 logK unit. The stability constants of the complexes Ln(EOB-DTPA)2- increase with increasing atomic number till the middle of the series. For the elements Tb to Ho the logKLnL values are approximately equal and a weak decrease can be observed for the heaviest elements, probably because of steric hindrance between the functional groups. The exchange reactions between the complex Gd(EOB-DTPA)2- and Y3+ ions occur predominantly through the formation and rate determining dissociation of the mono- and diprotonated complexes. The rate constants characterizing these reaction pathways are lower by a factor of three than the respective rate constants, known for the dissociation of Gd(DTPA)2-. On the basis of its higher kinetic stability, Gd(EOB-DTPA)2- can be used for in vivo investigations in medical diagnosis.

Original languageHungarian
Pages (from-to)89-96
Number of pages8
JournalActa pharmaceutica Hungarica
Issue number3-6
Publication statusPublished - Dec 1 2000


ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this