Complex interaction of yeast nuclear proteins with the enhancer/promoter region of SV40

Jeno Gyuris, László Dencso, Kornélia Polyák, Erno Duda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Though highly complex enhancers found in animal cells have not been reported to occur in yeasts they are able to activate the transcription of adjacent genes in yeast cells. Saccharomyces cerevisiae expresses a large number of nuclear proteins that are able to recognize, and specifically bind to, the enhancer sequences of the SV40 animal tumor virus. The complexity of proteins that interact with different elements of the animal enhancers is similar in yeast and animal cell nuclear extracts. Most enhancer motifs, recognized by known trans-acting factors, are protected in footprinting experiments by yeast nuclear proteins.

Original languageEnglish
Pages (from-to)359-363
Number of pages5
JournalCurrent Genetics
Volume20
Issue number5
DOIs
Publication statusPublished - Nov 1 1991

Keywords

  • Enhancer
  • Regulation
  • Transcriptional elements
  • Transcriptional factors
  • Yeast

ASJC Scopus subject areas

  • Genetics

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