Complex formation between transition metal ions and salicylglycine, a metabolite of aspirin

Elena Bermejo Gonzalez, Niamh Nic Daeid, Kevin B. Nolan, E. Farkas

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Ionization constant and complex formation constants of salicylglycine (1) in aqueous solution at 25°C and ionic strength 0.2 mol dm-3 KCl have been determined. The pKa values for the ligand are 3.44(1) and 8.24(4) and 1H NMR studies show that there is no further ionization at higher pH as was previously suggested. In the case of copper(II) there is no evidence for complex formation below pH 4 and the main species in solution at pH5 according to pH-metric and UV-vis spectrophotometric evidence in MLH- in which the ligand is bonded to the metal through the phenolate and carboxylate oxygen atoms and the deprotonated peptide nitrogen. The species ML also exists albeit in low concentrations. At pH10 the formation of MLH-2 resulting from ionization of an equatorial aquo ligand is observed. In the case of nickel(II) and zinc(II) no complex formation occurs below pH 6 but above this pH the species ML and MLH-1, the latter involving deprotonation of an aquo ligand, are observed although at pHca 8 in the case of nickel(II) and pH ∼ 7.5 in the case of zinc(II) precipitation occurs.

Original languageEnglish
Pages (from-to)1495-1499
Number of pages5
JournalPolyhedron
Volume13
Issue number10
DOIs
Publication statusPublished - 1994

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metabolites
Metabolites
Aspirin
Transition metals
Metal ions
metal ions
Metals
transition metals
Ligands
Ions
Ionization
Nickel
Zinc
ligands
ionization
Deprotonation
zinc
Ionic strength
nickel
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Complex formation between transition metal ions and salicylglycine, a metabolite of aspirin. / Bermejo Gonzalez, Elena; Daeid, Niamh Nic; Nolan, Kevin B.; Farkas, E.

In: Polyhedron, Vol. 13, No. 10, 1994, p. 1495-1499.

Research output: Contribution to journalArticle

Bermejo Gonzalez, Elena ; Daeid, Niamh Nic ; Nolan, Kevin B. ; Farkas, E. / Complex formation between transition metal ions and salicylglycine, a metabolite of aspirin. In: Polyhedron. 1994 ; Vol. 13, No. 10. pp. 1495-1499.
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